Analysis Of Drug Resistance Of Pseudomonas Aeruginosa And The Use Of Antibiotics In Children’s Wound

Objective: To study the drug resistance of pseudomonas aeruginosa(PA), and the correlation of the use of antibiotics, so as to provide forfuture treatment.Methods: A retrospective research of children who was admitted tothe children burn orthopaedic department because of traffic accidentinjuries during2009~2013. Data collections included patients’ generalcondition, the culture of wound, drug susceptibility and the usage ofantibiotics. Then divide patients infected with Pseudomonas aeruginosainto IPM-resistant and non-IPM resistant. Analyze the difference betweenthe two groups in the use of antibiotics.Result:(1) There were64pathogenic bacteria cultivated on thewounds, including Gram-negative bacilli, Gram-positve coccus, mould andso on. The top five are Acinetobacter baumannii, Pseudomonas aerginosa,Sewer e. coli, E. coli and Staphylococcus epidermis.(2) In the study all PA are multiple drug resistant strains and only sensitive to part ofbata-lactamase antibiotics, Aminoglycoside antibiotics andFluoroquinolones.(3) There is no statistical difference between the PA’ssensitivity to piperacillin-tazobactam and to piperaccillin.(4) There is moredrug resistance happened to the IPM-resistant than the non-IPM-resistant.(5) For patiens with PA, the most used antibiotics were Pentahydratecefazolin, Piperacillin-tazobactam, Ceftazidime, Imipenen, and so on.(6)There was no differentce in the treatment of antibiotic between theIPM-resistant and the non-IPM-resistant.Conclusions: PA is a common pathogen for traumatic wound. Its drugresistance situation is serious，especially for IPM-resistant. There was nocorrelation between the resistance to IMP and the usage of antibiotics in thestudy. By calculating the intensity of antibiotics, we found that the clinicaluse of antibiotics has yet to be improved.