A Clinical Study Of Efficacy Of Radiotherapy For Moderate-to-severe And Active Thyroid Associated Ophthalmopathy

Chart1MRI manifestations and pathologic character in thyroid associated ophthalmopathyObjective:To explore the influence of magnetic resonance imaging (MRI) on evaluating the activity in thyroid associated ophthalmopathy (TAO)Methods:We have enrolled6inpatients of TAO and7extraocular muscle in total in Xiangya2nd hospital of Central South University from Oct2013to Mar2014. They were measured T2signal intensity ration(T2SIR), which is calculated as the signal intensity of extraocular muscle and adjacent temporalis muscle in MRI before operation, and they received pathological examination after operation.We observed the relationship between MRI manifestations and pathologic character of the extraocular muscle.Results:1.MRI manifestations of active phase TAO:The belly of EOM increases significantly in2patients,and the average T2SIR is350%.The pathologic character is that a large number of inflammatory cells infiltrate between myofiber.2.MRI manifestations of stable phase TAO:The belly of EOM increases slightly in5patients,and the average T2SIR is133%. The pathology is characterized by muscle fibrosis.Conclusion:MRI T2SIR can be used as an objective quantitative measurements to evaluate the activity of TAO. Chart2A prospective,randomized, double-blind, internally-controlled clinical study of the efficacy of radiotherapy for active moderate-to-severe thyroid associated ophthalmopathyObjective:We want to evaluate the efficacy of radiotherapy for moderate-to-severe and active TAO by objective quantitative measurements.Methods:1.We have enrolled51outpatients with moderate-to-severe and active TAO in both eyes in Xiangya2nd hospital of Central South University form Feb2011to Feb2014.Patients were older than35years old,and there is no limit on the gender.2. We chose one eye randomizedly as experimental group and the other eye with sham radiotherapy as control group in one patient.Only the radiologist knew this, ophthalmologist and patients were double blind.The radiotherapy was given with6MV X-ray, the dose is20Gy in ten fractions over12days.3.We measured T2SIR、EOM volume and proptosis before radiotherapy and a month after radiotherapy, compared the change of these three datas of experimental group with control group, then analyzed the difference between two groups.4. We used statistical package SPSS version17.0for data analysis.Results:1.The reduction of T2SIR is (66.04±23.73)%in experimental group while (28.35±19.08)%in control group a month after radiotherapy. Compared the datas between two groups by paired sample t-test, the difference was statistically significant (p<0.01)2.The reduction of EOM volunme is (0.64±0.25)ml in experimental group while (0.20±0.19) ml in control group a month after radiotherapy. Compared the datas between two groups by paired sample t-test, the difference was statistically significant (p<0.01)3.The reduction of proptosis is (1.71±0.99) mm in experimental group while (0.53±0.56) mm in control group a month after radiotherapy. Compared the datas between two groups by paired sample t-test, the difference was statistically significant (p<0.01)Conclusion:It is effective that radiotherapy was used to treat moderate-to-severe and active TAO.