Effect Of MDR1Gene Polymorphism On Postoperative Fentanyl Analgesia In Patients

Objective:The purpose of this study was to explore the effect of MDR1gene polymorphism on postoperative fentanyl analgesia in patients undergoing radical gastrectomy.Methods:81patients of ASA physical status Ⅰ-Ⅲ, male or female, who were scheduled to undergo radical gastrectomy with general anesthesia were enrolled. Subjects received patient controlled intravenous analgesia(PCIA) to maintain NRS score (?)3postoperative48h. The fentanyl consumption and side effects were recorded during the first postoperative24h and48h. MDR13435C>T and1236C>T were genotyped by PCR-RFLP,2677G>T/A was screened by DNA sequence analysis after PCR amplified DNA. The statistical differences in fetanyl consumption and incidence of adverse effects were compared among genotypes and haplotypes at the first24h and48h after surgery.Results:There was no statistically significant difference in fentanyl dose among the SNPs of3435C>T,2677G>T/A at24h and48h after surgery(P>0.05). There was significant difference in fentanyl dose among the polymorphisms of1236C>T and the haplotypes of MDR1gene(P<0.05), TT genotype and TTT haplotype carrier need more fentanyl for postoperative analgesia. No significant difference in nausea, vomiting and dizziness was found at postoperative48h among3435C>T,2677G>T/A,1236C>T and their haplotypes.Conclusions:MDR11236C>T polymorphisms and the haplotypes composed by3435C>T,2677G>T/A and1236C>T are factors contributing to the individual variation in postoperative fentanyl analgesia.