The Correlation Of The Clinical, Pathology And Immunological Features In Patients With LN

Objective:To analyze the clinical and immunological features of123Chinese patients with lupus nephritis.Methodology:Analyze retrospectively the clinical characteristics, pathological category, immunological features and related factors of123patients with lupus nephritis.Results:①The ratio of female and male is6.24,age of onset in14to66years old,with an average age of32.51±11.10.②The renal histological classes showed class II (35.77%),Ⅲ(1.63%),IV(47.97%), V(14.63%).The proportion of class II in females was higher than that in males(39.6%vs11.8%, P<0.05).③Single factor analysis of clinical mainly for hair loss, buccal erythema, serous cavity inflammation, massive proteinuria, anemia, leukopenia, thrombocytopenia, SLEDAI, cystatin C in the differences between the pathological type group.④The LN pathological light and heavy Logistic regression analysis of multiple factors, the results shown in gender, anemia, heave proteinuria, cylindruria, cystatin C, blood and heavy LN positive correlation.⑤The incidence of immunological characteristic in patients with LN between the pathological group no signficant difference.Anti-double-stranded DNA antibody, anti-nucleosome antibody, anti-histone antibody are three kind of antibody positive patients with its pathological distribution has no obvious specificity(P=0.221); The SLEDAI score>9points32cases (97%),15points or more30patients (90.9%),have obvious difference (P=0.023).⑥22.8%of the patients with immune pathological expression is "light" and.12cases based on IgA deposits, IgM deposition, all female and ANA positive.Conclusion:①LN patients renal pathology to IV type, the most common followed by Ⅱ type.Male patients with IV, V LN common.②There is certain relationship between clinical features and pathological classifications in LN. Men, massive proteinuria, anemia, elevated cystatin C were the heavier risk factors of the renal pathological lesions in patients with LN.③LN patients SLEDAI at least9points, but there was no obvious correlation with pathological type.④Nephritis with mainly IgA deposits,as an atypical LN,may be a special subtype of SLE.