Risk Factors Of Hepatic Steatosis In Male Patients With Chronic Hepatitis B

Objective:To analyze the difference between male chronic hepatitis B (CHB) patients with or without hepatic steatosis in histological characteristics of inflammation and fibrosis,and to search for the risk factors of hepatic steatosis.Methods:Two hundred and nine male patients with CHB who were hospitalized for the first time and underwent liver biopsy from March2010to March2013were included in this study. The patients were divided into two groups according to the presence or absence of hepatic steatosis. Serum lipids, uric acid, glucose, alcohol consumption, obesity, overweight and HBV DNA load between the two groups were compared, and risk factors for hepatic steatosis were analyzed using binary logistic regression.Results:Among the209patients, there were121cases with (57.9%) and88(42.1%) without hepatic steatosis; Uric acid, low density lipoprotein and triglyceride were (352.5±87.1) mmol/L,(2.8±0.8) mmol/L and (1.8±0.1) μmol/L, respectively, in CHB patients with hepatic steatosis, all of which were remarkably higher than those in CHB patients without steatosis(310.3±69.1)mmol/L,(2.2±0.6)mmol/L and (1.2±0.7)μmol/L, respectively, P<0.01); Obesity, overweight and low density lipoprotein were the risk factors for hepatic steatosis(P<0.05).Conclusion:Obesity and hyperlipidemia, but viral load and alcohol consumption are the risk factors for hepatic steatosis in patients with CHB.