An Analysis Of Insulin Resistance And Impaired Glucose Tolerance In Patient With Obstructive Sleep Apnea Hypopnea Syndrome

Objective:To discuss the reason of insulin resistance and impaired glucose tolerance in patient with obstructive sleep apnea hypopnea syndrome(OSAHS). Methods:51patients who visited the sleep and breathe examination room in1st affiliated hospital of Xinjiang medical university from Jan2008to Apr2013met the inclusion criteria of OSAHS were selected and further divided into groups of mild, moderate and severe degree according to apnea hypopnea index and minimum pulse rate oxygen saturation, meanwhile selected a control group of71category matched patient, underwent OGTT between four groups, fasting plasma glucose,2hour post-prandial glucose, fasting serum insulin,2hour post-prandial insulin, glycosylated hemoglobin, total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and uric acid were tested, and then evaluate and calculate insulin resistance index using Homeostasis Model Assessment(HOMA). Data statistics were undergone applying Pearson chi-square test, one-way ANOVA and MANOVA. Results:Comparison between four groups showed that difference of epidemiologic data was not significant(P>0.05), body mass index(BMI), fasting plasma glucose,2hour post-prandial glucose, fasting serum insulin,2hour post-prandial insulin, glycosylated hemoglobin, homeostasis model assessment insulin resistance index(HOMA-IR) and uric acid were significantly different(P<0.05), difference of dyslipidemia status was not significant(.P>0.05), related analysis showed the existence of insulin resistance and prolonged peak value of insulin secretion in group of moderate and severe degree OSAHS. Conclusion:Abnormal glucose tolerance in OSAHS patients may due to insufficient insulin secretion, delayed insulin secretion, insulin resistance, decreased insulin sensitivity and islet dysfunction.