The Differences In The Curative Effect And Prognosis For Acute Myeloid Leukemia M2a Patients Cured By IA And DA Methods

Objective:aimed at finding effective therapeutic method for acute myeloid leukemia M2a (AML-M2a), IA program (idarubicin combined with cytarabine) and DA program (daunorubicin combined with cytarabine) were compared. In addition, the prognostic factors for AML-M2a patients were analyzed. Method:65AML-M2a patients’clinical data from May31,2009to May31,2013in the First Affiliated Hospital of Xinjiang Medical University was collected. Analyze the clinical characteristics, and then the curative effect, side effects and prognosis were studied. Adopt SPSS17.0statistical software to process data,P<0.05was considered significant differences. The survival curve was plotted using Kaplan-Meier method. In order to evaluate the independence of the prognostic value of the variable, the parameters with significant indicator (P<0.05) assessed by univariate analysis were introduced into COX regression analysis model. Results:﹊nduce complete remission rate and efficiency in IA and DA group didn’t show any statistical mean (P>0.05) despite of the higher values in IA group.②leukocyte minimum value in IA group (0.58±0.40)×109/L was obviously lower than that of DA group(0.99±0.67)×109/L,(P<0.05); compared with neutrophile granulocyte in DA group (0.22±0.16)x109/L, its minimum value in IA group(0.19±0.09)×109/L is lower, showing difference statistical mean(P<0.05); Neutropenia duration in IA group (12.59±5.31d) was much longer than that of DA group (9.17±7.04d),P=0.046.③the average survival time in IA group was36.67months, which was obviously higher than that of DA group (21.45months),(P<0.05).④the lactate dehydrogenase (LDH) value and Chemotherapy method were the independently hazard factors that could affect the prognosis of AML- M2a patients.ConcIusion:①in spite of the worse myelo suppression observed in IA program, IA program is in favorable of extending the median survival time and showed better longterm effect, suggesting it as the preferred initial treatment of chemotherapy AML-M2a.②Those persons who received IA method (LDH<1000U/L in the initial time) showed better prognosis. AML-M2a patients who adopted DA method (LDH≥1000U/L in the initial time) have poor prognosis.