The Role Of Autophagy In Renal Ischemia-reperfusion Injury

BACKGOUND: Autophagy, a highly regulated intracellular process,during which cellular long-lived proteins and organelles can be degraded tomaintain intracellular homeostasis. Accumulating evidence indicates thatautophagy plays a critical role in kidney injury, repair and aging. Ischemic,anoxia, toxic components injury, autoimmunity, and oxidative stress canlead the autophagy in renal epithelial cells and modifying the emergenceand development of various kidney diseases.OBJECTIVE: This review summarizes recent insights on the role ofautophagy in Renal Ischemia/Reperfusion Injury.METHODS: An electronic database search was conducted for articlesincluded PubMed, EMBASE and CNKI. from Janurary1998to June2013.The search terms were used as follows:“Autophagy”,“Ischemia/Reperfusion”,“kidney”,”renal”. EndNote7.0software was usedto remove duplicates. Finally44articles were selected for the review andanalysis.RESULTS AND CONCLUSIONS: Autophagy plays a crucial role inrenal ischemia/reperfusion injury. Regulating autophagy can affect theextent of reperfusion injury as well as its recovery.It may provide a new way for the prevention and treatment of renal ischemia-reperfusion injury.