Clinical Analysis Of23Cases Of Tuberculosis In Pregnancy

Objective: To summarize the clinical features， diagnosis andtreatment of tuberculosis in pregnancy, discuss the main risk factors fortuberculosis in pregnancy, find better way of the early diagnosis andtreatment of tuberculosis in pregnancy.Methods: A retrospective analysis of clinical and laboratory data ofthe tuberculosis patients during pregnancy (23cases) admitted in2011.01~2014.03of the First Affiliated Hospital of Chongqing MedicalUniversity.Results:1, this group of patients aged19-34years (mean26.70±3.87years), gestational age7+4-25+1weeks, five cases in earlypregnancy (21.74%),18cases in mid-pregnancy (78.26%).2,in the23patients,5patients with mild deficiency of albumin (21.74%);14patients with moderate deficiency of albumin in (60.87%);3cases thewith severe deficiency of albumin (12.04%).14patients with mildanemia (60.87%),8patients with moderate anemia (34.78%).3,in the23patients,18patients presented with recurrent fever (78.26%),21cases with cough and sputum which were more than two weeks (91.30%),15patients presented with chest pain (65.22%),6cases hadhot flashes, night sweats (26.08%), only1patient presented withhemoptysis (4.35%),2cases the presence of weight loss (8.70%).4,inthe23patients,19patients had respiratory failure (82.61%), including3cases of acute respiratory distress (13.04%);18patients withtuberculosis pleurisy (78.26%),4patients with extrapulmonarytuberculosis (17.39%).5,in the23patients,19patients underwent chestCT.5cases was hematogenous disseminated tuberculosis (26.32%),2cases was acute miliary tuberculosis (10.53%),3cases was subacutemiliary tuberculosis (15.79%);14cases was invasive pulmonarytuberculosis (73.68%).6,in the23patients,7patients with tuberculosisantibody positive (30.44%),2cases with sputum for AFB (+)(8.70%),4cases with sputum for AFB (++)(17.39%),3cases withsputum for AFB (+++)(13.04%), sputum for AFB-positive rate(39.13%);17patients underwent PPD skin test,2patients with PPDskin test (+)(8.70%),3patients with PPD skin test (++)(17.65%),and1patient with PPD skin test (+++)(4.35%), PPD skin test-positiverate (34.78%);7,in the23patients,22patients received anti-TBchemotherapy (95.65%), can be followed up in19patients,4patientshad gastrointestinal reaction (21.53%), one case had liver damage(5.23%),7cases had hyperuricemia (36.84%).8,in the23patients,2patients were lost to follow (8.70%), one case died due to treatment (4.35%) during hospitalization, one case died after abandon treatment(4.35%),5patients are improved during anti-TB chemotherapy(21.74%%);13patients cured after regular anti-TB treatment(56.52%).Conclusions:1, time of onset of tuberculosis is more in the secondtrimester of pregnancy;2, the majority of patients with varying degreesof hypoalbuminemia and anemia, which suggesting a protein-energymalnutrition;3the most common clinical manifestations of tuberculosisduring pregnancy were fever, cough and expectoration, less typical TBsymptoms as hot flashes, night sweats, weight loss, etc.;4,tuberculosis in pregnancy had a lower positive rate of PPD skin test,tuberculosis antibody and sputum for AFB, its diagnosis relies onimaging performance;5, heavy tuberculosis incidence of tuberculosisduring pregnancy, often associated with respiratory failure, tuberculouspleurisy, extrapulmonary tuberculosis;6, the cure rate is high whenpatient had regular anti-TB chemotherapy.