Correlation Between Human Leucocyte Antigen Polymorphism And Oral Lichen Planus: A Meta-analysis

Objective:To discuss the relationship between human leucocyte antigenpolymorphism and oral lichen planus, and to provide reference for theclinical prevention and treatment of oral lichen planus.Method:Searching for articles about the relationship between humanleucocyte antigen polymorphism and oral lichen planus by Embase, Medline,PubMed, Cochrane library, Web of Science, CBM, CNKI, VIP and Wanfangdatabase, and use the search engine to leak, collect all the relevant literaturesroundly. According to inclusion and exclusion criteria, two researcherscomplete relevant study selection and data abstraction independently.Included literatures were assessed using the Newcastle-Ottawa Scale(NOS),meta-analysis was conducted using Stata12.0, Odds ratios (OR) and95%confidence interval (95%CI) were pooled. Publication bias was assessed bydrawing a funnel plot, Egger’s regression test and Begg’s test.Result:A total of8case-control articles met the inclusion criteria andwere included.6articles involved in the Meta-analysis of HLA-DRB1*11 polymorphism and oral lichen planus, including396cases with oral lichenplanus and994controls. The allele frequency of case group is23.48%,control group is19.72%,8articles involved in the Meta-analysis ofHLA-DRB1*1polymorphism and oral lichen planus, including540caseswith oral lichen planus and3279controls. The allele frequency of case groupis15.0%, control group is9.85%.1. There is no statistic significant between HLA-DRB1*11polymorphism and oral lichen planus (OR=1.07,95%CI [0.59,1.94]), andsignificant heterogeneity was detected (P=0.012, I2=65.7%).2. There is significant differences between HLA-DRB1*1polymorphism and oral lichen planus (OR=1.36,95%CI [1.02,1.82]), andonly slight heterogeneity was detected (P=0.335, I2=12.2%).Conclusion:1.This meta-analysis showed there’s no strong evidence forassociation between HLA-DRB1*11polymorphism and oral lichen planus.2. This meta-analysis showed that HLA-DRB1*1polymorphism isassociated with risk of oral lichen planus, maybe HLA-DRB1*1is a riskgene for oral lichen planus.