The Research Progress Of Prostate Cancer And Autophagy

Autophagy is, evolutionary conserved, a process of genetic code,which play a significant role of keeping control the essential components,degradation of proteins and organelles of harmful, excessive or aging. Theresearch found that close relationship between autophagy and tumor, andautophagy play a crucial role in the progress and development of tumor.The occur of autophagy not only has important promoting effect on theprogress of prostate cancer metastasis, but prevent the prostate cancer cellsfrom changes in the internal environment, which can enhance drugresistance in prostate cancer. Autophagy promote a variety of protease,cytokines and genes including adenosine activation of proteases, monocytechemotactic protein1, tyrosine kinase, mad-7/IL-24and P21regulationimpact on prostate cancer, and cysmethynil, fisetin, metformin and2-DGinhibit autophagy which induced apoptosis of prostate cancer. Thus,Investigating the regulate mechanism of autophagy in prostate cancer, anddevelop of inhibitor of autophagy of drug, which could open a new avenuefor treating prostate cancer.