White Blood Cell Count And Type2Diabetes Artery Plaque

Type2diabetes（T2DM） is in high-risk for atherosclerosis,whichoften associated with coronary atherosclerotic heart disease (CHD), stroke,peripheral arterial disease (PAD). Atherosclerosis is the leading cause ofdisability and death in patients with type2diabetes. Carotid and the lowerextremity arterial plaque formation are common manifestations of type2diabetic atherosclerosis. The pathogenesis of type2diabeticatherosclerosis are unclear. Common risk factors include obesity,hyperlipidemia, high blood glucose,high blood pressure.Clinicalintervention often aims at controlling those risk factors. However,prevention and treatment of atherosclerosis of type2diabetes is notoptimistic. More mechanisms need to be discovered.Numbers of studies indicated that blood WBC were significantlyassociated with increased number of atherosclerosis. But those studies intype2diabetic patients are absent. Furthermore, confounding factors suchas obesity, hyperlipidemia and hyperglycemia may lead to misunderstandthe real role of WBC played in type2diabetic atherosclerosis.Our study recruited158patients with type2diabetes, in which123 patients underwent the carotid ultrasonography, and76others underwentlower extremity arterial ultrasound.They were divied into two groups basedon wether plaques existed. All patients underwent blood glucose,lipids,blood routine examination, DEXA examination. Gender, age, weight,BMI,duration of diabetes, SBP, DBP, hypertension and other factors arematched between two groups.We found that type2diabetes with lowerextremity or carotid atherosclerosis present elevated peripheral blood whiteblood cell counts and neutrophil counts. Logistic Regression analysis foundWBCC and NC were independently associated with carotid and lowerextremity artery plaque.When ROC curves were performed, the diagnosticmodels of WBCC and NC were both valuable,WBCC model AUC=0.640，P=0.008, NC model AUC=0.626，P=0.017. When the WBCC cut-off wasdefined as6.40×109/L，the sensitivity was0.60, specificity was0.70，YI=0.28；When the NC cut-off was defined as4.62×109/L,the sensitivitywas0.60,specificity was0.83,YI=0.24. We concluded that WBCC and NCwere linked with artery plaque closely.Furthermore,WBCC and NC couldbe useful biomarkers for screening of carotid arterial plaques.