Effect Of Rosuvastatin On Rats With Experimental Pulmonary Thromboembolism In Plasma NT-pro-BNP And IL-6Levels

[Objective]1.Whether the development of inflammation in pulmonary embolism.2.Discussion of rosuvastatin have effect on the treatment of pulmonary thromboembolism.[Methods] Choose healthy Wistar rats, male45weeks of age,6-8rats, weighing between180-220g, were divided in3groups, with15rats in each group, A group, B group, pulmonary embolism model group, group C was the experimental group (pulmonary embolism in rats by rosuvastatin intervention), the former via tail vein blood preparation font thrombosis, A, B group with normal saline for3days, group C with5mg/kg*d rosuvastatin gavage for3days, B, C group by intravenous injection of2ml saline containing embolus.24h three group rats, each rat4ml, BNP and IL-6concentrations were measured by double antibody sandwich method.[Results] Significant difference between A group and B group, C group and B group NT-pro-BNP, IL-6value (P<0.05), the plasma NT-pro-BNP in group A was (12.57±2.20) pg/L, B group, plasma NT-pro-BNP (42.14±4.52) pg/L, plasma NT-pro-BNP in group C was (21.03±1.98) pg/L; plasma IL-6in group A was (61.36±14.25) pg/L, Bgroup, plasma NT-pro-BNP (92.54±12.85) pg/L, plasma NT-pro-BNP in group C was (70.31±14.20) pg/L, A group and B group, C group and B group between difference statistical significance (P<0.O5).[Conclusion]1.Inflammation is involved in the development of pulmonary embolism.2.Rosuvastatin has effect on the treatment of pulmonary embolism.