The Clinical Observation Of Curative Effect With Ganglioside In The Treatment Of Intracranial Hemorrhage Of Preterm Infants

ObjectivesA rapid and non-invasive method of detecting fibrosis in patients with chronic liverdiseases is of major clinical interest. The purpose of this study was to assess thediagnostic accuracy and clinical utility for detecting liver fibrosis in patients withchronic liver disease by jointly measuring the real-time tissue elastography（RTE) andAST to Platelet Ratio Index (APRI) scores combined with liver biopsy.Materials and methodsThe study was performed under the approval of the ethical committee of the2ndAffiliated Hospital of Zhengzhou University. Sixty cases of chronic hepatitis patientswere included in the study. An informed consent was taken from all cases of patients.Blood samples were collected, and the regular laboratory tests were performedincluding the liver function, regular blood test, ultrasound examination, etc. AfterRTE was finished, the liver biopsy was performed. histology day ago ultrasonographyand liver function and blood testing, given RTE score by indicators of liver functionand blood serum aspartate within aminotransferase (AST), platelet (PLT),noninvasive diagnostic model APRI (APRI=[{AST (IU/1)/ULN (IU/1)}×100]/platelet count (109/L) calculated values, while a liver biopsy to assess to liver tissue biopsy pathology results as the gold standard diagnostic classification by Metavirpathological staging staging (no fibrosis, mild, moderate, severe fibrosis andcirrhosis) the resulting data were analyzed using SPSS19.0software system,measurement data (mean±standard deviation), said non-normal continuous data asmedian (interquartile range), said to≥F2as diagnostic criteria drawn subjects,the area under the curve analysis (Area under the receiver operating characteristiccurve, AUROC), the optimal cutoff value, calculated the sensitivity and specificity ofRTE and APRI. P <0.05was considered statistically significant. comparison alonereal-time tissue elastography (real-time tissue elastograph, RTE) diagnosis, APRIalone diagnosis, RTE joint APRI varying degrees of liver fibrosis diagnosticsensitivity, specificity.ResultsAs with regard for independently detecting the liver fibrosis in patients withadvanced stages of liver fibrosis, the sensitivity rates of real-time tissue elastography(real-time tissue elastograph, RTE) and APRI were0.824and0.971, respectively, andthe specificity rates were0.923and0.923, respectively. The values of RTE and APRIshowed a stepwise increase with liver fibrosis progression, and both RTE and APRIhad strong positive correlations with liver fibrosis stages (R=0.622,0.673respectively). With pathological findings≥F2as the criteria for diagnosingobvious fibrosis, the areas under the curve of RTE and APRI were0.948and0.947,respectively, its high diagnostic value. As for detecting advanced stages of liverfibrosis in patients with chronic hepatitis, the sensitivity and specificity of the RTEjoint APRI were0.781,0.963, and the accuracy was0.735respectively.ConclusionsRTE joint APRI can significantly improve the diagnostic accuracy for mild tosevere liver fibrosis and cirrhosis, RTE joint ARFI afforded excellent performancewhen used to diagnose advanced liver fibrosis, but differentiation of mild fibrosis wasin need of improvement especially for early detection.