The Clinical Observation Of Curative Effect With Recombinant Human Erythropoietin In The Early Treatment Of Neonatal Hypoxia-ischemia Encephalopathy

ObjectivesObserve the result of curative effect of Recombinant human erythropoietin(rhEPO) on (HIE) neonatal Hypoxi-ischemic Encephalopathy.MethodsAbout86cases of children with HIE were randomly divided into treatmentgroup (44cases) and control group (42cases). Two groups are regular treatment, thetreatment group on the basis of routine therapy, combined with rhEP0, according to250u/kg intravenous injection, day1, total course15d. Observed two groups ofchildren with neurological symptoms of recovery time, brain MRI changes, eachliving after7d,14d and28d for neonatal behavior neurological determination(NBNA),3months and6months after birth infants intelligence developmentassessment (CDCC).ResultsTreatment group of primitive reflex, muscle tension and the recovery timeconsciousness is less than that of control group (P <0.05)，Brain magnetic resonanceimaging (MRI) to improve the situation is better than that of control group (P < 0.05)，Born7d,14d and28d after treatment group NBNA scores were significantlyhigher than that of normal group (P <0.05), the treatment group3months and6months of mental development index (MDI) and psychomotor development index(PDI) are high.ConclusionsThe curative effect of early application of neonatal HIE rhEP0treatment issuperior to conventional treatment.