Extraction Of Ostrich Oil And Its Penetration Effect On Sinomenine

Ostrich oil is extracted from adipose tissue and contains unsaturated fatty acids. It is reputed to have exceptional penetrating and therapeutic qualities. Owing to the its remarkable permeability, ostrich oil has been considered as a promising carrier agent in combination with medicinal ingredients to deliver them beneath the skin barrier. However, published data on transdermal study of ostrich oil is extremely limited. In this paper, it includes the extraction of ostrich oil by supercritical extraction technology, the promoting performance of ostrich oil on sinomenine’s transdermal absorption, and synthetic evaluation of penetration enhancers by TOPSIS method, just as follows:1) The study of ostrich oil extraction by supercritical CO2, followed with GC-MS components analysis and physicochemical properties determination. It was found ostrich oil contained17kinds of fatty acids, and59.0%of them were unsaturated. while50.8%were mono-unsaturated fatty acids,82%were polyunsaturated. According to pharmacopoeia standards, five physicochemical index of ostrich oil were assessed:melting point (34.7℃), acid value (0.84mgKOH/g), saponification value (225.16mgKOH/g), iodine value (74.38gI/100g), and peroxide value (0.41gl/100g).2) The study of penetration enhancing effect of ostrich oil on percutaneous permeation of sinomenine. In Franz diffusion cells, ostrich oil was used as drug matrix and penetration enhancer, with reference to vaseline matrix containing different content of azone and oleic acid.24h later, the accumulative permeable amount of sinomenine(Q) in ostrich oil was143.97μg/cm2. And the zero equation was Q=6263t-0.374, while percutaneous endosmic rate constant was6.263μg/(cm2·h). It demonstrated ostrich oil produced stronger enhancement ratio (27.11) and shorter lag time (0.06h). According to the accumulative permeable amount of sinomenine, the density sequence was just as follows:ostrich oil>15%oleic acid>3%azone>2%azone>1%azone>10%oleic acid>5%oleic acid. 3) The synthetic evaluation of penetration enhancers. TOPSIS method was used to evaluate penetration effect of different enhancers and the density sequence was just as follows:ostrich oil>15%oleic acid>3%azone>2%azone>1%azone>10%oleic acid>5%oleic acid.The feasibility of ostrich oil utilizing as a promising vehicle for improving skin permeation of sinomenine was studied, and the effect of enhancers was synthetically evaluated. Ostrich oil was proposed as a promising penetration enhancer for cosmetics and pharmaceuticals.