The Analysis Of Cardiometabolic Profile About The Combination Of Prehypertension And Hyperhomocysteinaemia

Objective1.To investigate the concentration of homocysteine(Hcy) and related factors of hyperhomocysteinemia(hHcy) among non-hypertensive people aged40-70years in Tianjin.2. To analysis the effect on cardiovascular risk factors of prehypertension combined with hHcy.Methods Research1:Non-hypertensive residents aged40-70years were investigated by cluster random sampling from May2011to Dec.2012in six different Districts in Tianjin. Age, gender, smoking, drinking, exercise, education, consumption of vegetable and fruits, systolic blood and diastolic blood were collected; and874subjects were enrolled and divided into two groups:hyperhomocusteinaemia(hHcy, n=612) and normal homocysteine(Hcy, n=262). Hey was measured by an enzyme cycling method. Data analysis was conducted in SPSS17.0version. Hey≥10umol/L was defined as hHcy. Data are expressed as mean±tandard difference(x±s) for continuous variables and as percentages (%) for categorical variables. The comparison was conducted by Student t for continuous variables and χ2test for categorical variables. The factors of hHcy were analyzed in multivariate logistic regression models. Research2:Above enrolled subjects blood sample are collected from elbow vein after fasting10-12hours and measured for triglyceride(TG), total cholesterol(TC), high dense lipoprotein cholesterol(HDL-c), low dense lipoprotein cholesterol(LDL-c), uric acid(UA), fasting blood glucose(FBG), high sensitive C reactive protein(hs-CRP). All subjects are examined with oral glucose tolerance text(OGTT) for the measure of two hours postprandial glucose(2h-PG). The subjects are divided into four groups by blood pressure and hey:prehypertension with hHcy(Pre-HT+hHcy, n=356), prehypertension with normal Hcy(Pre-HT+Hcy, n=147), normotension with hHcy(NT+hHcy, n=245), normotension with normal Hcy(NT+Hcy, n=126), respectively. Data analyses are performed using SAS. Normal distributions variables are expressed as mean (95%confidence interval) and skewed distributions variables are expressed as geometric mean (95%confidence interval). TG, Hey, and hs-CRP are corrected by log-transformed for analysis. Multiple Comparisons among the four groups were calculated with ANOVA. Intergroup differences were calculated by Bonferroni test. categorical variables are expressed as percentages (%) and comparison was conducted by χ2testResults. research1:1. llcy is skewed distributions and the Hcy median(P25,P75) is12.0(9.3,15.0)μmol/L,14.5(11.1,17.1)μmol/L in male,11.4(8.8,14.1)μmol/L in female.2.hHcy group are older, more male, high education, less exercise, percentage of consumption of fruit and vegetable>500g/d than normal Hcy group (P<0.05). The smoking, drinking, SBP, DBP, BMI are null(P>0.05).3.The odd rate(95%Cl; P) for hHcy is1.532(1.094,2.145; P=0.013),2.572(1.198,5.520; P=0.015),0.504(0.298,0.850; P=0.010) for age, male, exercise, respectively; and0.097(0.037,0.255; P<0.001),0.043(0.016,0.116; P<0.001) for consumption of vegetable and fruits250-500g/d and>500g/d, compared with <250g/d.Research2.1. In multi-adjusted model, after adjusting for age, gender,et al.(1)There are null between Pre-HT+hHcy and Pre-HT+hHcy (P>0.05);(2) There are null between NT+hHcy and NT+Hcy (P>0.05);(3) Compared to NT+hHcy group, Pre-HT+hHcy have higher BMI、UA、TG (25.3vs23.5;317.6vs301.0;1.64vs1.30; all P<0.05);(4) Compared to NT+Hcy, Pre-HT+Hcy have higher BMI、hs-CRP (25.5vs23.6;2.06vsl.41; both P<0.05);(5) Compared to NT+Hcy, Pre-HT+hHcy have higher BMI、UA、TG、hs-CRP, and lower HDL-c (25.3vs23.6;317.6vs219.2;1.64vsl.28:1.94vs1.41;1.35vsl.48; all P<0.05);(6) Compared to NT+hHcy, Pre-HT+Hcy have higher BMI、2h-PG (25.5vs23.5;8.53vs7.17; P<0.05). TC, LDL-c and FBG are null among four groups (P>0.05).2. Further adjustment for BMI, compared with NT+hHcy and NT+Hcy, Pre-HT+hHcy have higher TG(1.56vs1.35;1.56vsl.32; both P<0.05). Pre-HT+Hcy have higher2h-PG than NT+hHcy(8.30vs7.32;P<0.05). There are null about UA, HDL-c, hs-CRP(P>0.05).Conclusion1. The Hcy meidan was12.0μmol/L, the percentage of hHcy was70%among non-hypertensives aged40-70in Tianjin. Male and age are risk factors for hHcy, consumption of vegetable and fruits, and exercise are favorable ones.2. The combination of prehypertension and hHcy synergically expressed the cluster of cardiovascular. Prehypertensives3. risk factors, which is related to BMI.Prehypertensives with hHcy have elevated TG independently of covariables.