| Objective:Bushenhuoxue law by observing the clinical application of knee replacement prosthesis after the surrounding bone loss and functional explore Bushenhuoxue law in the fight against bone loss around after knee replacement prosthesis and promote functional recovery after surgery on the advantages for provide an objective basis for the efficacy and optimize treatment program.Methods:According to the inclusion criteria of the February2013June2013Guangdong Provincial Hospital inpatient bone three knee replacement patients were randomly divided into a control group of methods and treatment groups, and ultimately into the data analysis in the control group,17cases, the treatment group had19cases, a total of36cases.6h after surgery began two groups were given calcium and calcitriol-based medicine (Caltrate+D tablets Rocaltrol) orally,1week after completion of the periprosthetic bone mineral density, bone metabolism indicators and measurement HSS score treatment group on the basis of the basis on the use of drugs of traditional Chinese medicine (Gusongbao capsules) orally; after three months, six months, nine months by dual-energy X-ray absorptiometry to measure postoperative false bone density around the body, after three months, six months, nine months when the bone metabolism laboratory follow-up,9months when assessed using the HSS score again after knee replacement function score. Collate the relevant data, the application of statistical software for statistical analysis, comparing the two groups of drug prevention and treatment of bone loss knee arthroplasty prosthesis clinical efficacy and functional differences in terms of recovery, while analyzing the lost around the prosthetic knee replacement surgery earlier law explore Bushenhuoxue law in the fight against bone loss around the knee replacement surgery and prosthetic limb to promote the advantages of functional recovery aspectsResults:Periprosthetic bone mineral density:ROI1District:within the same group at different time points after bone mineral density in comparison with the preoperative (P<0.05), described the two drugs were not prevent bone loss in knee replacement surgery ROI1region; two bone mineral density in patients early postoperative ROI1region was progressively reduced bone density curve slope a district can be seen from the front after nine months ROI, to reduce after3months before the most significant bone density after six months from the beginning of decline slowed; groups of patients at different times ROI1District bone density, the difference was not statistically significant (P>0.05); postoperative3months ROI1BMD changes in the amount of area the difference was not statistically significant (P>0.05), after six months, nine months after the change in ROI1area BMD, the difference was statistically significant (P<0.05), after different treatment groups period ROI1region BMD change were less than the control group. ROI Zone2:Within the same group at different time points after bone mineral density in comparison with the preoperative (P<0.05), described the two drugs were not prevent knee replacement surgery ROI2areas of bone loss; early postoperative patients were ROI Bone Density zone2showed a progressive decrease of bone mineral density changes can be seen from the front slope of the curve after nine months ROI2areas to three months prior to surgery to reduce the most significant bone density after six months from the began to decline slows; groups of patients at different times ROI2District bone density, the difference was not statistically significant (P>0.05); postoperative3months,6months after surgery, after nine months ROI2comparison, the difference was statistically significant (P<0.05) the change in bone mineral density areas, the treatment group after different periods of bone mineral density changes ROI2area were less than the control group. Description Application Bushenhuoxue law in the early postoperative knee replacement did not significantly improve bone mass in patients with periprosthetic, but can slow bone loss around after knee replacement prosthesis speed, thus reducing false knee replacement surgery loss of bone around the bodyBone metabolism:CTX:postoperative3months,6months after CTX values showed no significant difference (P>0.05), after3months,6months after the change in the difference was not statistically CTX significance (P>0.05), but after nine months CTX values and CTX after9months of the change in the treatment group was significantly better than the control group (P<0.05), and postoperative changes in different periods were less than CTX the control group, indicating that the application of the law Bushenhuoxue knee replacement surgery early osteoclast activity has a certain extent. PINP:two groups of patients after three months, after six months, nine months after PINP was no significant difference (P>0.05), but after three months, after six months, after three PINP month to change the amount of the treatment group than the control group (P<0.05), and postoperative changes in different periods of CTX were less than the control group, indicating that the application of the law Bushenhuoxue knee replacement surgery early osteoblast activity with a certain role in promoting.HSS function score:the same group of patients after treatment than before treatment HSS score comparison, the differences were statistically significant (P<0.05), two groups of patients after treatment HSS function scores were significantly better than before treatment; after nine months of treatment HSS score comparison group of patients with HSS score differences with the control group of patients was statistically significant (P<0.05), to restore function in patients after9months of treatment group than the control group, the difference between the two groups mainly in pain, and other aspects of the function and activity, and the difference was statistically significant (P<0.05); illustrate the application of law in Bushenhuoxue knee replacement surgery can promote early recovery of limb function, especially in pain, function and activity, etc. improving aspects. After nine months of treatment group excellent in15cases (79%), good in3cases (16%) in one case (5%), and poor in0(0%), in the control group were excellent in12patients (70%), good in4cases (24%), in one case (6%), and poor in0(0%), P>0.05, no significant difference between the two groups; illustrate the application of law in Bushenhuoxue knee replacement surgery did not significantly increase the early HSS patients rating functionConclusion:1knee replacement surgery early bone around the prosthesis decreased progressively to three months prior to surgery to reduce the most significant decline slowed from the start after six months; 2Joint Bushenhuoxue simple method compared with conventional western medicine with conventional Western medicine, which can slow the early postoperative prosthetic knee replacement bone loss around speed, thereby reducing the amount of knee replacement early bone loss around the implant surgery;3Bushenhuoxue law can promote early postoperative knee replacement recovery of limb function, especially in the post-operative pain, restore function and activity, the effect is significant, worthy of clinical application. |
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