The Study Of Jingu Capsule Combined With Percutaneous Vertebroplasty In The Treatment Of Osteoporotic Vertebral Compression Fracture

ObjectiveTo investigate the clinical efficacy of Jingu Capsule combined with Percutaneous Vertebroplasty in the treatment of Osteoporotic Vertebral Co mpression Fracture and to provide reference for standardization of Treatment of Osteoporotic Vertebral Compression Fracture.MethodDuring January of2012and October of2013, in patients of orthopaedics department of the Second TCM Hospital of Guangdong Province, who were diagnosed wih Osteoporotic Vertebral Compression Fracture and accoded with the TCM syndrome of "deficiency of liver and kidney disease" were randomly divided into the treatment group and the control group.23patients were distributed to the treatment group while22patients were enrolled into the control group. Both the two groups were treated with bilateral Percutaneous Vertebroplasty and prevention of infection, nutritional support, and the conventional treatment of osteoporosis (Rocaltrol0.25ug bid+Calcium Carbonate and Vitamin03Chewable Tablets0.5g bid). The treatment group were treated with Jingu Capsule(sig:4#tid) additionally. Both the two groups were ecouraged to walk with chest protector or waist support, avoding avoid lumbar flexion and lateral bending. The VAS scores and ODI scores of the two groups were measured and recorded before the operation, one day after the operation, one month after the operation, three month after the operation and half a year after the operation. The bone mineral density of the left femur neck were measured and recorded before the operation and half a year after the operation. Besides, clinical effect of the two groups were recorded half a year after the operation.Result.1There was no statastical difference in the baseline characters of the treatment group and the control group(P>0.05). The basline characters included age, course of disease, the number of fractures of vetebral, time of operation, blood loss during operation, the amount of bone cement (Page=0.270>0.05, Pcourse of disease=0.95>0.05.Pnumber of fractures of vetebral=1>0.05, number of fractures of vetebral=1>0.05,Pamount of bonecement=0.644>0.05, P blood loss during operation=0.271>0.05, Ptime of operation=0.129>0.05)2The Visual Anologue Scale:The VAS scores of the of both the treatment group and the control group before the operation were compared by Independent-Sample Test, showing no stastical statistical difference(P=0.361>0.05).The VAS scores of the two groups decreased with the advance of time (P=0<0.05). There was no significant difference between the two groups before the operation and one day after the operation (P=0.288>0.05) while there was statastical difference between the two groups one month after the operation, three month after the operation, and half a year after the operation (P1moth later=0.004<0.05, P three month later=0.003<0.05, P half a,ear later=0.002<0.05)3ODI score:The ODI scores of both the treatment group and the control group before the operation were compared by Independent-Sample Test, showing no stastical statistical difference (P=0.655>0.05). The ODI scores of the two groups decreased wiht the advance of time (P=0<0.05). There was no significant difference between the two groups before the operation and one day after the operation(P=0.407>0.05) while there was statastical difference between the two groups one month after the operation, three month after the operation, and half a year after the operation (P1month after=0<0.05, Pthree month after=0<0.05, P half a year later=0<0.05).4BMD:There is no statistical difference in the bone mineral denstity of the treatment group and the control group before the operation(P=0.756>0.05); The bone mineral density of the treatment group six month after the operation is higher than before the operation, showing statistical difference(P=0.03<0.05); The bone mineral density of the control group six month after the operation is higher than before the operation, showing no statistical difference (P=0.740>0.05).5Clinical curative effect:after treatment, the significant rate of the control group was39.13%, effective rate accounting for47.82%, the total effective rate88.96%; the significant rate of the treatment group was13.63%, the effective is54.54%, the total effective rate of68.19%. The total effective rates of two groups had significant difference (P=0.035<0.05)ConclusionJingu Capsule can relieve remanent back pain after Percutaneous Vertebroplasty, can improve bone mineral dinesty and can improve quanlity of life as well as self-care ability.As result, Jingu Capsule combined with Percutaneous Vertebroplasty is an effective way of treating Osteoporotic Vertebral Comression Fracture. The method is of preferable clinical value and worthy of further study..