Comparisons Of Clinical Effects In Patient With Polycystic Ovary Syndrome That One Drug Or Different Combinations Have

Objective:In the most frequent gynecologic endocrine diseases，polycystic ovarysyndrome is the one which is often accompanied by fat and insulin resistance(IR).In thetreatment of patients with PCOS coupled with insulin resistance，a number of differentstudies have revealed that the confederated oral administration of contraceptives andinsulin sensitization agent can produce better results.This study compares the remedyoutcomes of three types of therapeutic schemes,which including Diane-35,Diane-35andMetformin, Diane-35and Metformin and Pioglitazone, in PCOS patients with IR inorder to explore more effective treatments.Method：By collecting sixty one PCOS patients’ clinical data, which were in themeantime merged with IR,we divided the patients into three groups:group A(treatedwith Diane-35)including20cases,group B(taken Diane-35and Metformin)including20cases,group C(treated with Diane-35and Metformin and Pioglitazone)including20cases.The standards of sex hormone,fat in serum and BMI,insulin of them have nosignificantly differences before the treatment.After three months’ treatment,thestandards of all the patients’ gonadal hormone,fat in serum,insulin were examined bycollecting their venous blood.Comparisons of the BMI pretherapy and post-treatment ofthree months were taken,along with the clinical observation for one-three months,therate of ovulation,as well as the pregnancy rate in different groups were compared. Result:After the treatment,the levels of LH,T and LH/FSH of the three groupswere significantly declined(P<0.01).The levels of FIN and BMI of group A(treated withDiane-35) has no significantly decreased(P>0.05),but they were significantly decreasedin both of group B(treated with Diane-35and Metformin) and group C (treated withDiane-35and Metformin and Pioglitazone)(P<0.01,P<0.05),and FIN in group C goteven lower than group B(P<0.05).The abnormal lipid metabolism was not adjusted ingroup A(P>0.05),as well as the standards of HDL-C,TC and LDL-C in group B,but thelevel of TG in group B was significantly declined(P<0.05).In group C,the levels of TCand TG were lower(P<0.05) than before,the level of HDL-C was higher(P<0.05)thanbefore,and FIN in group C got even lower than group B(P<0.05).The ovulation rate andpregnancy rate have upgrade trend but have no significantly difference(P>0.05)．Conclusion：This paper exhibited that, hyperandrogenemia is corrected in thesethree therapeutic schedules．But IR and abnormal lipid metabolism are adjusted only inDiane-35plus insulin sensitizer groups.Compared with Diane-35plus Metformin,thecombination scheme of Diane-35,Metformin and Pioglitazonehas has a morecomprehensive therapeutic effect.