Survival Analysis: A Retrospective Study Of Eighty Cases Of Synchrony Multi-primary Lung Cancer

Background: As the development of diagnostic techniques, the incidence of synchronymulti-primary lung cancer (SMPLC) has increased. However, the diagnostic standardand treatment strategies remain to be improved.Objective: The aim was to explore the prognostic risk factors and evaluate therelationship between prognosis and surgery treatment by analyzing the clinical dates inpatients with SMPLC retrospectively.Methods: The clinical data of80cases of SMPLC from Mar.2008to Mar.2013wereanalyzed retrospectively. We explored the prognostic risk factors including age, gender,smoking, tumor location, surgical approach, histological type, differentiation, lymphnodes metastasis, TNM Stage, visceral pleural invasion, and evaluate the relationshipbetween prognosis and surgery treatment by Kaplan-Meier survival analysis and Coxregression multivariate analysis.Results: The incidence of synchrony multi-primary lung cancer was3.44%(80/2325)in all lung cancer cases. The major patients were female (58.75%) with the middle ageof62years old, adenocarcinoma (76.25%), double lesions (85%). Survival analysismodel found that smoking history (p=0.045), lymph node metastasis (p=0.028),histological type (squamous-squamous carcinoma p=0.028, mixed carcinoma p=0.045)，differentiation (high differentiation, p=0.048), CEA(P=0.003) and the numbers of tumor(P=0.027) were the independent risk factors for prognosis. Analysis of the effect of thenumbers of tumor on prognosis showed that tumors at difference pulmonary lobes(p=0.02), CEA (P=0.003), the surgical method (p=0.02) and postoperative recurrence(p=0.043) have statistical significance. The1,3,5-year survival rate were92.3%,26.1%and5.2%respectively.Conclusion: The incidence of synchrony multi-primary lung cancer was low. The majorpatients were female with the middle age of62years old, adenocarcinoma and doublelesions. Patients with smoking history, lymph node metastasis, squamous-squamouscarcinoma, differentiation,CEA＞5ng/ml and three tumors had poor prognosis. There was no difference between surgical method and prognosis.