Effect Of Sevoflurane Postconditioning On NO、ET-1and Myocardial Enzymes Of Patients Following Cardiopulmonary Bypass Valve Replacement

Objective To investigate the Sevoflurane postconditioning on No、ET-1、cTnI and cK-MB of patients following cardiopulmonary bypass valve replacement.Methods30patients accepted elective mitral valve replacement surgery with cardiopulmonary bypass were divided into2groups (Group S and Group C).2%Sevoflurane was inhaled through membrane oxygenator before blocking ascending aorta and opening ascending aorta for10minutes in patients from group S. No Sevoflurane was inhaled in patients from group C.Results Compared with group C, the expression of ET-1is lower while the NO、 cTnI and cK-MB are higher in group S in T1、T2、T3、T4.(P<0.05). Compared with T0,the expression of ET-1、NO、cTnI and cK-MB gradually increased and reached a peak inT2(P＜0.05)Conclusion2%Sevoflurane inhaled through membrane oxygenator in early ischemia/reperfusion following cardiopulmonary bypass can increase NO and decrease ET-1and myocardial enzymes thus protect myocardial.