Preliminary Study On The Correction Of Cranial Imaging, EEG And Therapeutic Effect In Children With Epilepsy

Objective: To preliminary evaluate the correlation between cranialimaging，electroencephalogram (EEG) and therapeutic effect, weretrospectively analyzed the cranial imaging, change of EEG and therapeuticeffect of106children with epilepsy, who were diagnosed in our neurologicaloutpatient and ward.Methods: We collected106children with epilepsy diagnosed by clinicseizures, cranial imaging and EEG in neurological outpatient and ward ofChildren’s Hospital of Chongqing Medical University from August2011toJanuary2013. And all of them took antiepileptic drugs (AEDs) regularly. Allcases had EEG and cranial imaging examination. Duration time of follow-uplasted at least6months after taking AEDs, and the number of follow-upwere3times at least. We observed the control of seizure, change of EEG,cranial imaging, and adverse drug reaction of AEDs. The therapeutic effectwas evaluated by the control of seizures.Results:114cases were taken into the initial group, but8cases wereexcluded after lost follow-up, so only106cases were involved in the final group, in which12cases had drug withdrawal and3cases died.61caseswere male and45cases were female, aging from1month to12years old,average age were5.02±3.71years. Whether the therapeutic effect waseffective or not was decided by the control of seizures, effective controlincluding completely control and partially control. Results of different groupwere:1. imaging normal group (67cases) and imaging abnormal group (39cases), the therapeutic effect between these two groups had significantdifferences (χ2=6.47，P<0.05).2. EEG normal group (11cases) and EEGabnormal group (95cases), the therapeutic effect between these two groupshad no significant difference (P>0.05).3. Both cranial imaging and EEGabnormal group (38cases) and not both cranial imaging and EEG abnormalgroup (68cases), the therapeutic effect between this two groups hadsignificant differences (χ2=7.15，P<0.05).4. Group of EEG back to normal(45cases) and group of EEG sustained abnormal (61cases), the therapeuticeffect between these two groups had significant differences (χ2=10.33，P<0.05).5. Group of ADR absent (86cases) and group of ADR (20cases), the therapeutic effect between these two groups had no significantdifference (P>0.05). The Retention rate was80.70%(92/106cases).Conclusion:(1) The cranial imaging (MRI or CT) is a significant factor for thetherapeutic effect of children with epilepsy, with abnormal imaging thetreatment of efficiency is lower than that with normal; (2) EEG sustained abnormal is another significant factor for thetherapeutic effect of epilepsy in children, with EEG sustained abnormal thetreatment of efficiency is lower than that back to normal;(3) With both cranial imaging and EEG abnormal the treatment ofefficiency is lower than normal imaging and EEG;(4) The current total therapeutic effect of oral AEDs therapy in childrenwith epilepsy is satisfied. Various AEDs have well tolerance, highretention rate and less ADR in children with epilepsy.