Study On The Effet Of Escitalopram Oxalate On FD Patients With Psychological Barriers

Background and ObjectiveFunctional dyspepsia(FD), that is a very common disease in digestive diseases, it is based on no organic disease, systemic or metabolic diseases.FD patients performances of a range of chronic indigestion symptoms such as postprandial fullness of the upper abdominal discomfort, early satiety, pain, burning and so on,which is caused by the abnormal function of the gastrointestinal tract and other factors. FD does not seem to result in an increased risk of long-term health, but it significantly reduces the quality of life of patients. Although FD is one of the most common disorders in digestive diseases, its treatment is more difficult. Inhibitors of gastric acid secretion and promote gastrointestinal motility drugs are usually the the FD first line of treatment medication, however, the effectiveness of these two types of drugs is limited, there are more patients with FD symptoms can not be relieved or complete remission. At the same time, we found that FD patients are often tend to have mood disorders such as anxiety and exhibit symptoms of depression, but also increase the patient’s perception of symptoms. The purpose of this study is to observe the curative effect of Escitalopram Oxalate Tablets (Lexapro) on FD patients with psychological barriers.MethodsFifty-six cases patients with FD and psychological barriers were researched, who were not response to antacids, prokinetic drugs and other symptomatic treatment in the First Affiliated Hospital of Zhengzhou University between November2011and November2012.These patients had been treated with starting dose of Escitalopram Oxalate of5mg, and it was continue used for3months.Follow-up contents included indigestion symptoms, sleep, depression and anxiety. Curative effect of Escitalopram Oxalate was analyzed. ResultsDuring treatment,3patients less than treatment requires time limit self-withdraw,one patient not taking medications regularly,2cases were lost, and50cases were included in the cases of Statistics.The number of indigestion symptoms improved was38, sleep improved was30, depression improved was26and anxiety improved was1after treatment. Maintenance dose of5mg after onset was30cases,10mg of20cases. After treatment, dyspeptic symptoms, sleep disorders, depression compared with before treatment, the difference was statistically significant (24%VS100%, P <0.05;16%VS76%, P<0.05;34%VS86%, P<0.05). Anxiety before and after treatment, the difference was not statistically significant (20%VS18%, P>0.05).ConclusionEscitalopram Oxalate can effectively improve the FD and psychological disorders in patients with symptoms of indigestion, sleep disorders and depression at the same time improve the patient’s symptoms.It can not effectively improve the patient’s anxiety symptoms.