| Aim:Recently many evidences have shown:obesity not only induces many diseases, but also become an economy burden to family and social.5-HT has a variety of physiological functions. Most of studies have shown that many5-HT receptors subtypes are involved in the regulation of feeding behavior via activating the corresponding5-HT receptors subtypes. Therefore, the aim of the present study was to investigate the role of5-HT3receptor on control of feeding behavior and c-Fos expression in fed and fasted mice.Results:Fasted mice was injected intraperitoneally (i.p.) with5-HT3receptor agonist SR57227, food intake were measured at1,3and6h. The high-dose SR57227(10mg/kg, i.p.) significantly inhibited food intake in mice in1,3h but not6h.The effect of SR57227on feeding behavior was blocked by5-HT3receptor ondansetron; In addition, SR57227(10mg/kg, i.p.) significantly enhanced the c-Fos expression in the brain stem (DMV, NTS and AP) and hypothalamus (PVN, DMH, VMH, and ARC) in fed group and fasted group, and this enhancement was also blocked by5-HT3receptor antagonist ondansetron.Conclusion:Above studies indicate that activation of5-HT3receptor can inhibit food intake in fasted mice. These effects may be related to the neural activity of nucleus tractus solitarius, dorsal motor nucleus of the vagus nerve, area postrema, hypothalamic arcuate nucleus, paraventricular nucleus, ventromedial nucleus of the hypothalamus and dorsomedial nucleus of the hypothalamus. Therefore, these findings suggest that the5-HT3receptor may play an important role in feeding behavior under fasting conditions. |
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