Effect Of Ethyl Acetate Extract Of Pomegranate Fruitage On Glucose And Lipid In Type2Diabetic Rats

Objective: In this study of fresh pomegranate fruit products, fresh products will becut and dried pomegranate, soaked extracted with ethyl acetate to give the ethylacetate extract of pomegranate fruit PFEA. By studying the effect of PFEA on the ratsmodel of Type2diabetic fasting blood glucose (FBG), fasting insulin (FINS), insulinsensitivity index (ISI), triglycerides (TG), free fatty acid (FFA) intervention effect,evaluate whether it has to improve the effect of type2diabetes and explore itspharmacological effect, provide a preliminary basis for PFEA used in clinicalexperiments.Methods: A high-fat high-sugar, high salt diet with streptozotocin (STZ)intraperitoneally twice (30mg kg-1) to establish a rat model of Type2diabetic, andFBG values≥11.1mmol L-1was established as Standard molded. With PFEA100mg kg-1,200mg kg-1,300mg kg-1administered intervention four weeks, givingpositive drug rosiglitazone (ROG)3mg kg-1. In modeling the normal dose group at4weeks, and PFEA high, medium and low dose group and began administering PFEA200mg kg-1. Respectively, in the first four weeks of modeling, administration of thefirst two weeks, the first four weeks of dynamic fasting blood glucose (FBG), insulin(FINS), insulin sensitivity index (ISI), triglyceride (TG) concentrations. Measuredafter4weeks of administration (FFA) concentrations..Results: Compared with the normal group, model group FBG, FINS, FFA, TG levelsincreased significantly, ISI levels decreased (P<0.05or P<0.01); weeks after modeling, the normal group and model group rats FBG, FINS, TG were5.94,30.71,0.57mmol L-1;13.05,42.36,1.62mmol L-1; Administered four weekslater,compared with the model group, the ethyl acetate extract of pomegranate fruiteach dose group FBG, FINS, FFA, TG levels were significantly reduced, a rat modelof Type2diabetic was significantly increased, and the difference was statisticallysignificant (P<0.05or P<0.01).Conclusions: In this study, high-sugar, high-fat, high-salt diet feeding withstreptozotocin (STZ) intraperitoneally twice (30mg kg-1) successfully copied the ratsmodel of Type2diabetic. This model is in line with human clinical diseasecharacteristics. PFEA by adjusting the experimental rat model of insulin resistance,fasting blood glucose (FBG), insulin (FINS), insulin sensitivity index (ISI),triglycerides (TG), free fatty acid (FFA) levels, improve and play therapy experimentsthe role of the rats model of Type2diabetic.