The Clinical Observation Of Efficacy And Safety About Wen Drug Point Application In Treatment Of Advaced Lung Cancer

ObjectiveIn this prospective controlled clinical studies, we aimed to evaluate the efficacy and safety of wen drug acupoint application in advanced lung cancer, and to evaluate its benefit to patients an its feasibility, safety. Providing basis for clinical use of wen drug acupoint application and its promotion in the advanced lung cancer.MethodsThrough this prospective randomized controlled clinical trials,64patients who met the inclusion criteria were included. All of them were come form Check First Affiliated Hospital of Guangzhou University of TCM Oncology Department from April2013to March2014. They were randomly divided by random sampling method into acupoint sticking therapy group and the control group (32cases). Both of the two groups were treated orally and I needed nutritional support therapy and TCM Fuzhengyiliu. Point to Acupoint sticking therapy group posted on this basis. In this group we adopted the bilateral Feishu, Geshu, spleen, once a day, very4to6hours,14days for a course. the control group was not point application. Observed the clinical symptoms after treatment, quality of life, Karnofsky score, tumor-off changes, immune function, satisfaction and adverse events, and used SPSS19.0in statistical analysis. ThereforeResultsBoth of the two groups and the two disease types of Acupoint sticking group had the ecqual baseline before treatment. They were comparable. After nutritional support therapy and TCM Fuzhengyiliu all indicators showed signs of improvement.1. The comparison between acupoint sticking group and control group:1)Acupoint sticking group had the total effective rate of80%which was higher than the control group (60%), but their validity had no significant difference (P=0.11>0.05)2) Acupoint sticking group got more improvement of clinical symptoms than the control group(P<0.001), where respiratory symptoms. gastrointestinal symptoms, mental consciousness improved significantly, especially for respiratory symptoms improvement which were significant difference, mainly performance in the improvement of cough, expectoration, chest tightness, chest pain, gas promote (P<0.05), while blood in sputum no obvious improvement.(P>0.05).3)There were no significant difference in the change of CEA, Karnofsky score, body weight, changes in solid tumors, blood, liver and kidney function between the acupoint sticking group and the control group.4)The two groups showed improvement tend in the quality of life in each template after treatment. Acupoint sticking group showed better improvement in the template of physiological conditions, functional status, additional circumstances, which had Statistical significance (P<0.05). While In the social/family template had no significant difference (P>0.05)5)After the treatment the two groups had the total T Cells and Th Cell increased, but their change had no Statistical difference (P>0.05). In the Acupoint sticking therapy group, the Ts cells and NK cells increased after treatment, while the control group decreased. The two group shows significant difference (P<0.05).6)Satisfaction between the two groups was Statistical difference(P <0.05), acupoint sticking group was better than the control group. There were no adverse events happened in the gastrointestinal tract, such as skin reactions, vital signs, blood system, liver and kidney function. Incidence of adverse events in both groups had no statistical difference.(P<0.05)2. The comparison between two two disease types of acupoint sticking group:In the acupoint sticking group, the effective rate of lung spleen deficiency syndrome was92.86%, while the other was68.75%. Their difference has no significant (P>0.05). The two diseases type were Statistical difference in the improvement of, functional status, and additional conditions after treatment (P<0.05), while no statistical difference in immune function, blood, liver and kidney function, CEA, KS score, weight, solid tumors change satisfaction and adverse events(P>0.05).ConclusionOn the basis of nutrition support therapy and TCM Fuzhengyiliu, the using of wen drug acupoint application would better improve respiratory symptoms, gastrointestinal symptoms, as well as the quality of life and immune function in patients, especially for respiratory symptoms improved significantly, mainly in the improvement of cough, expectoration, chest tightness, chest pain, gas promoting symptoms. Acupoint application was more pronounced for lung spleen deficiency syndrome patients in the improvement of cough, expectoration, chest tightness, as well as the life of quality such as functional status, and additional conditions. Throughout the course, the-patients had good satisfaction and safety. Therefore Wen Drug Point Application was more than a safe and effective adjuvant therapy in the treatment of advantage lung cancer and was worthy of clinical promotion.