The Comparative Study Of Concentrate Growth Factors (CGF) And Platelet-Rich Fibrin (PRF) Degradation In Vitro

Objectives:To make further understanding of Concentrate Growth Factors (CGF) biological characteristics and evaluate its clinical value, the characteristics of CGF and PRF degradation in artificial saliva and their biological degradation speeds were studied.Methods:10volunteers were selected in the study.18ml venous blood in two vacuum blood collectors from each volunteers were placed into the drum of the Medifuge centrifugal acceleration machine, to separate CGF and PRF specimens, according to the preparation process.Both CGF and PRF specimens were made into blocks and membranes separately, and then were immersed in artificial saliva with37℃constant water bath. The qualities of the specimens in blocks and the area of membranous specimens were measured at fixed times, to record the degradation process of CGF and PRF.The graph of the degradations was made to learn the degradation characteristics of CGF and PRF, and compare their degradation speeds.Results:There were differences in degradation speeds for CGF and PRF in blocks in artificial saliva. The degradation speeds for CGF membranes and PRF membranes were also different.All the data were processed in SPSS18.0. The Repeated Measures ANOVA was carried out among groups, and when P<0.05, the differences were significant.Conclusions:1. In the artificial saliva, regardless of the specimens in blocks or in membranes, the degradation speeds of CGF were slower than that of PRF.2. Both CGF and PRF have fibrin frame works. The degradation speeds associated with the content of fibrin. The degradation speed for CGF is slower than the PRF, which indicates that it’s fibrous protein content is higher, and it can play a stronger biological reproduction function.