| Objectives: Diabetes mellitus (DM) can lead to cognitive decline and structuralabnormalities of the brain,but the exact mechanisms remain unclear. The objective wasto explorer the relationship between DM and abnormal white matter (WM)microstructural changes in old type2diabetic patient,by magnetic resonance DiffusionTensor Imaging (DTI).Research Design and Methods: DTI was performed in22patients with type2diabetes mellitus (T2DM) and in25sex-and age-matched healthy volunteers. Thefractional anisotropy (FA) of several WM regions were analyzed by using a tract-basedspatial statistics (TBSS) technique. We also determined the correlation between plasmaNε-(Carboxymethyl)lysine (CML) level and mean FA of the whole WM as well asMMSE and MoCAscore of the T2DM group.Results: The total scores of MMSE in the T2DM and control groups were25.72±3.13and28.16±2.45respectively, and was considered to be statistically significant (P <0.05).The total scores of MoCA in T2DM and control groups were22.15±3.56and25.63±4.12.Statistically analysis showed significantly difference (P <0.01).FAof patients with T2DMwas decreased in the corpus callosum, cingulate fasciculus, inferior fronto-occipitalfasciculus, parietal WM, hippocampus and temporal lobes in comparison with thecorresponding regions of healthy controls. FA of the WM in the frontal lobe, occipitallobe and internal capsule of patients was not significantly different from that in controls.A significant negative correlation was observed between plasma CML and FA values inthe global WM (r=-0.58, P <0.01), and there was also a negative correlation betweenCML and Montreal Cognitive.Assessment (MoCA) scores (r=-0.47, P <0.05).Conclusions: Our results show that WM microstructure changes occur in old patientswith T2DM.CML may play a role in pathogenesis of diabetic cognitive impairment. |
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