The Expression And Clinical Implications Of PPARγ And Bcl-2in Non-small Cell Lung Cancer Tissues

Objective: To investigate the expression of PPARγ and Bcl-2proteins in humannon-small cell lung cancer tissues, lung tissues and the correlation of this two indicators.We analyze the relationship between their biological characteristics. It will providetheoretical basis for the prognosis and the important basis of applying PPARγ ligandsand Bcl-2blockers to therapy non-small cell lung cancer in the future.Methods: MaxVision TM methods were used to detect the expression of PPARγ andBcl-2in137cases of NSCLC paraffin histopathological tissues and37cases of lungtissues. SPSS20.0statistical software was used for statistical analysis, and p-value lessthan0.05were considered significant. The correlation between the indicators and themajor clinical characteristics of NSCLC were analyzed by chi-square test.Results:1. The positive expression rate of PPARγ and Bcl-2in NSCLC tissues was50.4%and45.3%， respectively. The positive expression rate of PPARγ and Bcl-2inadenocarcinoma tissues was44.3%and45.2%，respectively. The positive expressionrate of PPARγ and Bcl-2in squamous carcinoma tissues was77.3%and45.5%，respectively. The positive expression rate of PPARγ and Bcl-2in lung tissues was16.2%and2.7%, respectively. The different positive rates between NSCLC and lungtissues had statistical significance (P<0.05).2. The expression of PPARγ and Bcl-2was not correlated with gender, age, smoke status（P＞0.05）.3. The positive expression rate of PPARγ in squamous carcinoma tissues was77.3%，higher than44.3%in adenocarcinoma tissues. The positive expression rate of PPARγ intumor size more than3cm tissues was72.2%, higher than the other two groups. Thepositive expression rate of PPARγ in lymph node metastasis patients was64.7%, higherthan44.7%in non-lymph node metastasis patients. The positive expression rate ofPPARγ in clinical stage Ⅱ+Ⅲ patients was63.6%, higher than43.0%in clinical stageⅠpatients. The different positive rates between those groups had statistical significance(P<0.05).4. The expression rate of PPARγin tumor size more than3cm tissues was65.0%, higherthan37.9%in tumor size less than2cm tissues. The different positive rates betweenthose groups had statistical significance (P<0.05).5.The expression rate of Bcl-2was correlated with tumor size（P＜0.05）. Theexpression of Bcl-2was not correlated with pathological types and histologic classes，lymph node metastasis and clinical stage（P＞0.05）.6.There were significant positive correlations between PPARγ and Bcl-2in NSCLC（P＜0.01,r=0.388）.Conclusion:1. The positive expression rates of PPARγ and Bcl-2are significantly higher in NSCLCthan lung tissues. This result showed that PPARγ and Bcl-2may play an important rolein the occurrence and development of NSCLC.2.PPARγ was correlated with tumor size, pathological types and histologic classes，lymph node metastasis and clinical stage. This result suggested that the indicators wereclosely correlated to the metastasis of NSCLC.The higher positive expression ofPPARγ proteins was indication for the tumor growing quickly and the disease stagebeing later and lymph node having metastasis.3. Bcl-2was correlated with tumor size. This result suggested that the indicators wereclosely correlated to the tumor growing of NSCLC.The higher positive expression ofBcl-2proteins was indication for the tumor growing quickly. 4. The expression of PPARγ and Bcl-2proteins in NSCLC was related to each other.PPARγ and Bcl-2had together taken part in the oncogenesis, development in NSCLC.5. The positive expression rate of PPARγ is significantly higher in NSCLC than lungtissues. Our results provided the important basis of applying PPARγ ligands to therapylung cancer in the future.