Platelet Activation In Elderly And Aged Tumor Patients

Objective: The aged are highly susceptible to various diseases, includingmyocardial infarction, stroke, chronic obstructive pulmonary disease, cancer, etc. As theworld is entering the aging society, both domestic and foreign scholars commit to theprevention and treatment of the senile diseases. Previous studies have demonstrated thatthe platelet activation in the aged is involved in multiple diseases, and it is closelyrelated to the senile diseases. Platelet parameters and activation markers in diseaseshave arisen more attention recently, and the antiplatelet therapy continues to improve. Itis of great importance to prevent the old-aged disease; some scholars believe that thereason for platelet activation in elderly people is aging. However, there are few reportsabout the association of the platelet activation and aging. The purpose of the study is todetect the relationship of the platelet parameters, activation markers and age, and toinvestigate the association between platelet activation and age.Malignant tumor is one of the main diseases that threaten the health of the elderly.Platelet granule stores the growth factors that related to tumor metastasis, and it can besecreted extracellular to promote or inhibit angiogenesis after activation of platelet.Whether elderly patients with cancer have higher platelet activation ratio and whetherthe secretion of growth factor is the cause of cancer remain unknown. This studycompared the levels of platelet activation markers and platelet related growth factorsbetween healthy elderly and aged tumor patients, and analyzed the correlation betweenplatelet activation and elderly cancer.Methods:1. We used statistics analysis method to compare the platelet parameters in thehealthy young adults (25-45years old), the aged (≥60years) examined in our hospitalmedical center and the aged tumor patients of the tumor department between theSeptember and December in2012.2. We examined the platelet activation marker CD62P positive rate in the blood ofhealthy young adults, the elderly and aged tumor patients using Flow Cytometry CellMethod.3. Plasma content of platelet factor4(PF4) and connective tissue activating peptideⅢ(CTAP-Ⅲ) in healthy young, elderly and aged tumor patients using enzyme linkedimmune sorbent assay(ELISA). Result:1. PLT in the healthy young adults group, the elderly group and aged tumor groupare expressed as (±s) and were（236±51）×109/L,（214±54）×109/L and（258±92）×109/L respectively. PLT in aged tumor group was significantly higher than healthyyoung adults group, while PLT in the healthy young group was significantly higher thanthe elderly group (P＜0.01). MPV in the three groups were （10.45±0.78） fl,（10.41±0.79）fl and （10.13±1.02）fl respectively. MPV in aged tumor group wassignificantly lower than the other groups, while there was no difference between healthyyoung adults and aged group (P＞0.05). Age and PLT were negatively correlated（r=-0.19）.2. The positive rate of CD62P increased gradually from healthy young adults group,the elderly group to aged tumor group, which were （12.89±6.70）%、（20.37±9.52）%and （34.77±10.29）%respectively, and the differences between each of them werestatistically significant (P＜0.05).3. Both the levels of PF4and CTAP-Ⅲ in plasma in aged tumor group weredecreased than in healthy young and aged group, but there were no statisticaldifferences (P＞0.05).Conclusion:1. CD62P positive rate in the blood was increased with aging, while the changes ofplatelet parameters were not significant.2. Both platelet parameters and CD62P positive rate in aged tumor patients wereincreased than healthy group, the platelet related growth factor was closely related to theoccurrence of tumor.