Sodium Thiosulfate In The Rat Vascular Calcification Of Intervention And Mechanism

Objective: Vascular calcification (vascular calcification) is atherosclerosis, theprevalence of common pathology of hypertension, diabetic vascular disease, vascularinjury, chronic kidney disease and aging, etc., mainly for increased vessel wallstiffness, reduced compliance, easily lead to myocardial ischemia and left ventricularhypertrophy and heart failure, causing thrombosis, plaque rupture, is one of theimportant factors of cardiovascular disease with high morbidity and high mortality;also atherosclerotic cardiovascular events, cerebrovascular an important marker ofstroke and peripheral vascular disease occurred. The traditional notion has been thatvascular calcification is a passive, degradation inevitably terminal process, however,recent clinical and basic research results indicate that the development of vascularcalcification process similar to the formation of bone and cartilage, is an active, canadjustable cure and prevention process. This article can observe thiosulfate treatmentof vascular calcification in uremic rats and preliminary discussions related to thepathogenesis of vascular calcification, in order to better treatment of vascularcalcification in uremic patients.Methods: SD rats with experimental pellets containing750mg/kg adeninefeeding7w, artificial rat model of uremia. Normal control group NUC, uremic ratsgroup UC, uremic rats+thiosulfate group UC+STS.10rats in each group, includingfive males and five females. After the rats were fed with adenine seven weekssuccessfully established rat model of uremia, uremic rats+sodium thiosulfate be ratsby intraperitoneal injection of sodium thiosulfate each0.5kg/kg three times a week forfive weeks, while the normal control group and the group of rats with the sameamount of uremic rats given saline injections three times a week for5weeks. Animalswere sacrificed at12weeks. Rat blood serum SOD, MDA levels were measured inplasma of rats in each group MGP Fetuin law by ELISE-A level. ApplicationSPSS17.0statistical software for data analysis. Results: Compared with normal control group, plasma SOD activity decreaseuremic rats increased MDA levels, the difference was significant (P <0.05). SODactivity in rat plasma sodium thiosulfate treatment group decreased and MDA levelsincreased by a certain degree of inhibition, the difference was significant (P <0.05),compared with the control group, the level of uremic rats MGP and Fetuin-Asignificantly lower. And after thiosulfate uremic rats after treatment, the blood MGPand Fetuin-A levels than untreated uremic rats blood MGP and Fetuin-A levelssignificantly increased (P <0.05).Conclusions: thiosulfate to treat and reduce uremic vascular calcification in rats.Sodium thiosulfate can increase plasma MGP and Fetuin uremic rats-A level, therebyinhibiting vascular calcification occurs, and sodium thiosulfate, through itsantioxidant properties, thereby reducing oxidative stress, improve endothelial function,which it may be one of the mechanisms preventing calcification.