Investigation Of Motion Susceptibility In Migraineurs

Objective Compare the incidence of motion sickness among different populations and compare the correlation between motion sensitivity and the severity of headache in migraine patients to assess the motion sensitivity of the migraine patients as to investigate the feasibility of motion susceptibility for specific diagnosis of migraine symptoms. Compare and analyze the co-morbidity of movement susceptibility, vertigo and motion sickness in migraine sufferers to explore the possible onset of a common pathogenic pathway. Then evaluate the motion sensitivity in patients with migraine under different types of stimulus to looking for the possible risk factors associated with the occurrence of motion susceptibility in order to further explore the related prevention and treatment of the symptom.Methods60patients with migraine,30patients with tension-type headache and30patients without headache were selected randomly from September2013to February2014in Neurology Outpatient of Shandong Provincial Hospital. The general information and detailed medical history of all subjects and the level of headache severity and motion sickness were collected. Visual analogue scale and Graybiel symptoms score were used respectively. All patients underwent2questionnaires including Motion Sickness Susceptibility Questionnaire and Visual Vertigo Analogue Scale during headache intermittent. Data analysis was done with SPSS21.0software package. The measurement data were described as mean±standard deviation x±s. The measurement data was analyzed with chi-square test the count data among different groups was analyzed with t test. The difference was considered statistically significant when P<0.05.Results1. The motion sickness incidence in migraine group was46/60(71.7%). The Graybiel score was10.37±7.48. The incidence and score were14/30(46.7%) and4.78±6.51in tension-type headache group respectively and which were12/30(40.0%) and2.31±3.42in healthy control group. The incidence of motion sickness and Graybiel scores of migraine group were obviously higher than that of the tension-type headache group and the healthy control group. There was a significant statistical difference (P<0.05).2.The number of migraine attacks in migraineurs with motion susceptibility was17.9±8.3/month. The duration of headache was11.4±7.9h. The associated symptoms were2.4±0.8. And the scores of headache degree were7.3±2.2. Which were all higher than those migraineurs without motion susceptibility (9.7±6.2/month4.8±3.7h1.5±1.2and3.6±1.4scores respectively)(P<0.05).3.29out of60cases of migraine sufferers had motion susceptibility during migraine attack in which43cases had motion sickness and17cases had vertigo. And25of them had both movement susceptibility and motion sickness accounting for25/29(86.2%) in the migraine suffers with movement susceptibility.12patients had both motion susceptibility and vertigo accounting for12/17(70.6%) in the patients with vertigo. There was a significant statistical difference in both groups(P<0.05).4.There were significant differences in age (P=0.030) and aura (P=0.047) between the migraineurs with and without motion susceptibility. But there were no significant statistical differences in sex (P=0.347) menstrual relevance (P=0.867) and familial background (P=1.00) respectively. Which meanes there was a higher incidence in young and with aura migraineurs with motion susceptibility.5.The incidence of motion susceptibility of migraineurs when traveling in cars was58.3%which was45.0%when traveling in buses. And it was84.2%when traveling in cars while reading. Which were all higher than those of tension-type headache suffers (23.3%16.7%and44.8%respectively)(P<0.05). But there were no significant statistical difference between the two groups when traveling in trains (P=0.859) aircraft (P=0.964) small boats (P=0.185) and large ships (P=0.686) and playing on playground equipment (P=0.615) and funfair rides (P=0.494).Conclusionsl.The incidence and severity of motion sickness in migraineurs were significantly higher than that of the tension-type headache patients and the general population. And more severe the headache, the higher the likelihood of motion susceptibility occur. Compared to the other people, there was a significant statistical difference of the incidence of exercise intolerance in migraine patients. So motion susceptibility can be used as one of the diagnostic symptoms of migraine.2. The migraine sufferers with motion sickness were more likely to appear exercise intolerance during migraine attack and were more likely to appear vertigo under visual stimulation when being intolerant to movement. So there was co-morbidity among motion susceptibility、vertigo and motion sickness in migraine sufferers.3. The motion susceptibility symptoms may be more likely to appear in young patients and those migraine with aura patients. Common linear acceleration movement stimuli such as traveling in cars and buses may be more likely to lead to the occurrence of exercise intolerance.