Investigating The Relatingship Between Helicobacter Pylori And Hepatocelluar Carcinoma

Objective To investigate the relatingship between Helicobacter pylori and hepatocelluar carcinoma.Methods We Collected clinical datas of the patiens who had been frist diagnosed primary hepatocelluar carcinoma cases and the patients with non-cancer in Guangxi Medical University Cancer Hospital from March2010to October2013. C-14breath tests had been taken to detect the Helicobacter pylori before the gastroscopy examinations in our hospital gastroscopy department. Totally311of patients with hepatocellular carcinoma were collected and87patients with non-cancer were collected to control group. There were no signifigantly diferrent between the two groups aboat age and sex.And then two groups datas were collected from the patients of311with hepatocellular carcinoma. One group patients were detected of HBV-DNA copy number and the value of Helicobacter pylori14C-UBT;The other group patients showed AFP concentrations and the value of Helicobacter pylori14C-UBT. As far as was concerned count dates,compareing rates of Helicobacter pylori, we used software of SPSS16.0to the chi-square test. However, measurement datas were involved, correlation analysis was used to analysised the collected datas.Test level Q was0.05.Results The positive rate of Helicobacter pylori in patients with primary liver cancer(61.4%) was obviously higher than the non-cancer patients’s(28.7%). The difference was statistically significant. With respect to cell differentiation, The positive rate in poorly differentiated hepatocellular carcinoma cells(48.9%) was the highest among moderately differentiation(39.2%) and well-differentiated (28.5%). According to the mean rank about the cell differentiation (separately47.5,171and258in poor, moderate and good cell differentiation), it seems that the more poor of the cell differentiation, the more higher the postive rate. The rate in phase III/IV was significantly most high than the other two. The result of average rank implied the more later of the clinical stage, the more higher the postive rate of Helicobacter pylori infection.. Hp high positive rate of of liver cancer patients with invasive infections; The rate in highly invasive(59.7%) was higher than minimally invasive(26.1%).Chi-square test results were X2=21.025, P<0.05. Bile duct cell type infection rate (61.1%) was significantly higher than the other two types, and the difference was statistically significant. Gender, age differences were not significant.The correlation coefficient between the value of Helicobacter pylori14C-UBT and alpha-fetoprotein concentration was OR=0.88, however was OR=0.657between the value of Helicobacter pylori14C-UBT and HBV DNA copy number. Both of the two groups Chi-square test results were P<0.05. As the the number of HBV DNA copies and concentration of alpha-fetoprotein were rising, the postive rate of Helicobacter pylori infection was higher and higher. Conclusion Helicobacter pylori infection was associated with the occurrence and the development of primary liver cancer.