Plasma Amino-terminal-brain Natriuretic Peptide Precursor,Troponin Ⅰ, Fiber Prothrombin Fragment1+2Assay For The Diagnosis Of Pulmonary Embolism

Objective To investigate the value of plasma amino-terminal-brain natriuretic peptide precursor (NT-pro-BNP), troponin I (cTnI), fiber prothrombin fragment1+2(F1+2) determination in the diagnosis of pulmonary embolism.Methods The trial included38patients confirmed pulmonary embolism (PE) in PE group. Patients were divided into20cases of right ventricular dysfunction group,18patients without right heart dysfunction group, according to the patients have cardiogenic shock or low blood pressure and right ventricular dysfunction. over the same period, select40cases of the age and sex matched healthy control group. Separately determine the value of NT-pro-BNP, cTnI and F1+2.Results (1)The NT-pro-BNP levels in the three groups of patients showed significant differences: compared with normal control group (44.36±23.27pg/L), the NT-pro-BNP concentrations of right ventricular dysfunction group (4621.89±3661.52pg/L) and without right ventricular dysfunction group (492.45±761.29pg/L) were significantly increased(P<0.05); NT-pro-BNP concentrations in patients of right ventricular dysfunction were significantly higher than those without right ventricular dysfunction group (P<0.01).(2)The cTnI concentration in RVD group(1.83±0.47ng/ml)and without RVD group(1.26±0.63ng/ml) was significantly higher than those in the control group (0.41±0.17ng/ml),P<0.05;And RVD group were significantly higher than those without RVD (P<0.05).(3)The F1+2concentration in RVD group (271.89±167.01nmol/L) and without RVD group(218.61±117.39nmol/L), was significantly higher than those in the control group (41.90±29.74nmol/L), P<0.05; there was no significant difference between RVD group and without RVD group(P>0.05).Conclusion The concentration of NT-pro-BNP、cTnI and F1+2in PE patients are significantly higher than the control group, which have practical clinical significance for the diagnosis of PE. THE concentration of NT-pro-BNP and cTnI were proportional to the severity of PE.