Severe Intracranial Arterial Stenosis Associated With Non-alcoholic Fatty Liver Research

Objective:To investigate intracranial arterial stenosis and non-alcoholic fattyliver, theory and data basis for clinical prevention and treatment of intracranial arterial disease caused due to non-alcoholic fatty liver disease (NAFLD).Methods:January2012-2012in December in the hospital Neurology inpatient30-75year old intracranial artery stenosis with non-alcoholic fatty liver disease cases (male patient cases, cases of female patients) for within the United prevalence group, of simple intracranial arterial stenosis patients in the control group.Color ultrasound diagnosis of non-alcoholic fatty liver disease, non-alcoholic fattyliver disease (NAFLD) diagnostic criteria with reference to the "non-alcoholic fatty liver disease treatment guidelines. Diagnosis of intracranial arteries by transcranial color Doppler ultrasound (TCD) severe stenosis the The detection site selection of the M1segment of the intracranial middle cerebral artery (MCA-M1), theanterior cerebral artery (ACA), posterior cerebral artery (PCA), neck the end of the artery (TICA), the siphon of the internal carotid artery (ICA siphon), vertebral artery (VA) and basilar artery (BA), by two experienced clinicians make ultrasound diagnosis. Determination of the two groups of patients with BMI (body mass index), WC (waist circumference), HOMA-IR (insulin resistance index), CHOL(cholesterol), TG (triglycerides), hs-CRP (high-sensitivity C-reactive protein), TNF-alpha (tumor necrosis factor), APN (adiponectin) level, through the appropriateindicators to assess the relevance of non-alcoholic fatty liver disease with intracranial arterial stenosis.Results:The joint prevalence of BMI (body mass index), WC (waist circumference), HOMA-IR (insulin resistance index), CHOL (cholesterol), TG (triglyceride) levels were significantly higher than that in the control group; suffering fromjointthe disease group hs-CRP (high-sensitivity C-reactive protein), TNF-alpha (tu mor necrosis factor) water was significantly higher than that in the control group,APN (adiponectin) was significantly lower than the level of simple intracranialartery severe stenosis control group;the results of this study also showed that thejoint prevalence group BMI and HOMA-IR were significantly positive correlation between HOMA-IR and APN was a significant negative correlation between abdominal obesity, abnormal adiponectin and insulin resistance inherent relationship.Conclusion:NAFLD and intracranial arteries with stenosis is closely related to intracranial arterial stenosis early independent markers; and this association is independent of the typical risk factors (such as IR, abdominal obesity, etc.). NAFLD patients compared with the general population, the risk of death. The NAFLD by up-regulating TG synthesis, decreased the TG metabolic transformation capacity, reduce circulating TG scavenging accelerate the development and progression of intracranial arterial stenosis.