Clinical And Metabolic Characteristics Of Patients With Autoimmune Diabetes In Adults(LDAD)

Objective The purpose of this study was to explore the clinical and metaboliccharacteristic of latent autoimmune diabetes in adults (LADA), so as to provide basisfor take more effective interventions in patients with LADA.Methods212cases of patients attending hospital-based diabetes clinics were divided into the Latent autoimmune diabetes in adults group102cases(male56cases, female46cases),Type1diabetes(male29cases,female15cases) and Type2diabetes(male33cases, female33cases). Record the general informationof the patients include gender, age, height, weight, disease duration, history ofhypertension,and calculate the index weight(body mass index, BMI); all patientswere detected and record Systolic blood pressure(SBP), Diastolic blood pressure(DBP), Fasting plasma glucose(FPG),2-hour post-meal blood glucose(2hPG), hemoglobin A1c(HbAlc), cholesterol (CHO), triglyceride(TG), high density lipoprotein cholesterol(HDL-c), low density lipoprotein cholesterol(LDL-c), And calculate the insulin resistance index.Results①C ompare the general information: The statistical analysis shows genderand diabetes duration had no significant difference among the three groups(P>0.05),ages had also no significantly between LADA and Type2diabetes (P>0.05). Whilethe age and BMI of type1diabetes had significantly lower than LADA and type2diabetes(P<0.05). History of high blood pressure and SBP,DBP had no significantlydifference between the LADA and type2diabetes or LADA and type1diabetes (P＞0.05). While SBP,DBP had significantly difference between type1and type2diabetes (P<0.05).②Assessment of the Serum indexes, HbA1c obey normaldistribution, The rest FPG, CHO, TG, HDL-c, LDL-c after natural logarithmtransformation for normal distribution data. Results suggest that FPG, CHO, HDL-c,LDL-c were no significantly difference among the three groups(P>0.05),2hPG and HbA1c in patients with LADA were significantly higher than in those with T1DM andT2DM (P<0.05), While2hPG and HbA1c were no significantly difference betweenT1DM and T2DM. TG in patients with LADA and T1DM were significantly lowerthan in patients with T2DM (P<0.05), while there are no significantly differencebetween T1DM and T2DM.③T heTests suggest that different types of diabetes prevalence of metabolicsyndrome have significant difference. The highest prevalence of metabolic syndromeis type2diabetes Groups, LADA set times, while type1diabetes groups is lowest.④T heTests analyze the distribution of different components of the metabolicsyndrome between the three groups. Suggests that each merger of components of themetabolic syndrome, such as hypertension(SBP≥140mmHg, and or DBP≥90mmHg orhad history of hypertension), overweight and obesity(BMI≥25kg/m2), high bloodtriglycerides(fasting blood TG≥1.7mmol/L) and low HDL ester(fasting bloodHDL-C<0.9mmol/L (35mg/dl)(male),<1.0mmol/L(39mg/dl)(female), there is nostatistically significant differences(P>0.05).Conclusion①T he clinical and metabolic features of patients with LADA, type1diabetes, type2diabetes have significant differences, of which, the generaldemographic differences mainly displays in the age distribution, body mass index, etc;Metabolic characteristics mainly in blood glucose, blood lipid, blood pressure;②T he statistical analysis results the highest prevalence of metabolic syndrome is type2diabetes Groups, LADA set times, while type1diabetes is lowest;③T he distribution of different components ofthe metabolic syndrome(hightriglyceride,overweight and obesity,low high-density lipoprotein cholesterol (HDL-c)ester,hypertension) among the three groups there were no significant difference;④The HOMA-IR of LADA with metabolic syndrome was higher than withoutmetabolic syndrome.