| Objective：To investigate the change of Th17and CD4+CD25+Foxp3+regulatory Tcells(Treg) and related cytokines in patients with viral myocarditis(VCM).Methods：62VCM patients were divided into three groups including34VMC patients inacute phase,15patients in recovering phase,13patients in chronic phase, and30individuals were selected as healthy control. The percentage of Th17/CD4+T cell inthe peripheral blood from patients and controls were detected by flow cytometry. Theplasma level IL-17, TGF-β and anti-heart antibodies (AHA) were detected byELISA in all specimens.Results：The positive rate of AHA was61.3%in VMC patients, which were much higherthan control group(6.7%),(P<0.01). The ratios of Th17, Treg cells and relatedcytokines IL-17, TGF-β were increased significantly on acute, persistent andchronic cases, when compared with normal control and recovering cases(P<0.05).Conclusion：The ratios of Th17and Treg cells are increased significantly on acute,persistent and chronic VMC cases. This may indicate that the imbalance of Th17/Treg cells may be one important reason for the occurrence and development of viralmyocarditis. |
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