Meta Analysis Of The Death Cause In Severe Acute Pancreatitis In China

Objective: Severe acute pancreatitis(SAP), which develop urgent, ferocious, andcause higher mortality [1] was treated difficultly.It was reported that different regionshad the different death factors of severe acute pancreatitis, that there was no unifieddiagnostic standard in the related literature. Through this study, we would further explorethe risk factors of the died SAP patients, and improve our understanding and thediagnosis and treatment.Research methods: According to the research subject retrieval strategy, twoindependent evaluation members searched1814related literatures in CNKI, ChinaInfo,VIP, Embase, Pubmcd, SCI database. The33related literatures was obtained by theinclusion criteria and exclusion criteria from the total1814related literatures. ToEvaluating33literatures according to the nine grade evaluation method and To designforms data extraction and extracting data by the basic principles of the PICO and tofurther reduce the results of the study of "heterogeneity", there was screened17relatedliteratures since2000, in which Analysis the factors affecting the SAP death by Metaanalysis. The analysis factors included gender, age, etiology (gallstone, alcoholconsumption, high triglycerides, overeating, other), APACHE II score, Ranson score,Balthazan score and computed tomography (CT) severity index, single organdysfunction/failure, multiple organ dysfunction/failure, pancreatic pseudocyst, totalbilirubin, serum creatinine, serum calcium and blood sugar, prothrombin time, bloodwhite cells and red blood cells deposited, amylase, blood urea nitrogen, urinary amylase,proportion of red blood cells, total cholesterol, triglycerides, blood Ph, serum albumin,ARDS, infection, pancreatic encephalopathy, shock, acute renal failure (ARF) andmultiple organ dysfunction syndrome (MODS), cardiovascular dysfunction, respiratorydysfunction, acute liver dysfunction, gastrointestinal dysfunction, acute renal dysfunction,pancreatic necrosis. Research results:This study found that in severe acute pancreatitis was heavier,the disease mortality is higher, men than women, the ratio of about1.4:1, the overallmortality rate of15.83%. Included the literature was given priority to with the easternregion, but the most published literature was in Sichuan province of China.The SAPpatients were mainly concentrated in tertiary hospital. Increasing death factors were acuterenal failure, computed tomography (CT) severity index, shock, MODS, red blood cellsdeposited, urea nitrogen can increase the SAP mortality. Possible Increasing death factorswere Age, APACHE II score, multiple organ dysfunction/failure, serum creatinine, serumcalcium and blood Ph, serum albumin, ARDS, pancreatic encephalopathy, cardiovasculardysfunction, respiratory dysfunction, gastrointestinal dysfunction, acute renal dysfunction.The gender, pathogeny (biliary disease,, alcohol consumption, high triglycerides,overeating, other), Ranson score, Balthazan score, a single organ dysfunction/failure,pancreatic pseudocyst, total bilirubin, blood sugar, prothrombin time, blood white cellsand blood amylase, urine amylase, triglycerides, total cholesterol, infection, acute liverfunction obstacle, don’t increase the risk of death of SAP.Research conclusions: CT severity index, acute renal failure, shock, MODS, red bloodcells deposited, urea nitrogen are the risk factors of death of SAP.