Polymorphisms Of Vitamin D Receptor And Serum25(OH)D Levels Are Associated With Prognosis Of HBV Related Acute On Chronic Of Liver Failure

Objective: To analyze the association of polymorphisms for BsmI、ApaI、TaqI at the vitamin d receptor locus and serum levels of25(OH)D with the prognosis of HBV related acute on chronic liver failure.Methods: We performed a case‐control study，a total of153HBV related acute on chronic liver failure patients and HBV carriers were included with a followed up of3months. The polymorphisms for BsmI、ApaI、TaqI at the vitamin d receptor locus and serum levels of25(OH)D were analysed, and the cases survival rate were evaluated.Result: Of the153HBV related acute on chronic liver failure patients, the sur-vival rate is74.51%. The b allele and genotype bb of BsmI SNPs were morefrequently in HBV related acute on chronic liver failure patients (p＜0.001and p＜0.05,respectively).Either in survival group or in death group that b allele is more frequent than B allele(P=0.016，OR=0.467).Genotype bb was more frequent in death group than genotype BB and Bb（74.14%VS12.07%VS13.79%），and also genotype bb was more frequent in death group than in survival（74.14%VS38.60%，P＜0.001，OR=4.614）.HBV related acute on chronic liver failure patients had more lower25（OH）D concentration than HBV carrr-iers（10.40±2.92VS19.02±5.69ng/ml，P＜0.001）, lower25(OH)D concentration inversely correlate with MELD scores(rr=‐0.558), Concentrations of25(OH)D in death was lower than in survivals（8.18±2.23ng/ml VS11.29±2.70ng/ml，P＜0.001）.Basing on Kaplan‐Meier analyses, serum25(OH)D concentration were associated with poor prognosis.Conclusion: Our results suggest that polymorphisms in vitamin d receptor are associated with prognosis of HBV related acute on chronic liver failure patients, and lower concentration of25(OH)D may suggest a poor prognosis, these findings could be helpful in identifying individuals at risk for bad outcomes and prompt physicians to offer more active treatments.