Clinical Analysis Of Three Drugs By Bladder Perfusion To Prevent Recurrence Of Superficial Bladder Tumor

Objective By observing clinical effect of pirarubicin(THP),hydroxycamptothecin (HCPT),mitomycin C (MMC) in the process of bladderperfusion, effective methods were found for preventing bladder tumor recurrence anddiscuss its clinical value.Methods There were141patients with superficial bladder cancer whichwas f-ound the first time, including THP group being51cases, HCTP groupbeing47cases, MMC group being43cases.Those patients who were post-operation were poured THP, HCPT and MMC into bladder respectively in24hours or at once firstly by indwelling catheter.Then three groups of patients startedblad-der perfusion every week after operation. Patient need to be told to keepurine emptying before pouring drugs into bladder.THP group were asked to change their position (supination,prone,side-lying)once every10minutes after routine di-sinfection and drugs perfusion. HCPT group and MMC group were asked to c-hange their position once every30minutes.THP which were poured into the b-ladder were reserved for half of hour. HCPT and MMC were reserved for t-wo hours.Preparation method are first once every seven days, eight ti-mes in a row, after1times a month,10times in a row, the total course of52weeks. All patients of bladder perfusion review their routine urine and kidney functio-n and cystoscopy within1year every3months,then experience reexamination once every half of yea-r.Observe and record every time after bladder perfusi-on drug-induced bladder irritation symptoms, blood in urine and secondary effe-cts in the period of treatment.If suspicious lesions were found in the course o-f cystoscopy, we affirmed whether it was the recurrence of SBC byt-he mean of pathological examination.Results Post-operative patients who were followed up two years created thefollowing results:the tumor recurrence rates of three groups in6months was7.8%.THP group, HCTP group, MMC group after six months was5.88%,4.26%and13.96%respectively, and there was no obviously statistical difference(P>0.05);the tumor recurrence rates of three groups in12months was14.1%.THP group,HCTP group, MMC group was9.80%,8.51%and25.58%respectively,and there wasobviously statistical difference (P＜0.05); the tumor recurrence rates of three groupsin24months was18.44%.They were13.73%,10.64%and32.56%respectively, andthere was statistically significant difference (P＜0.05). the total incidence of theother side effect was17.73%.The incidence of bladder irritation symptoms of threegroups was respectively17.65%,12.77%,37.21%,and statistical difference wasobvious (P <0.05); The incidence of cruenturesis of THP was1.96%and MMC was6.98%.The incidence of cruenturesis of HCPT was not found and there was noobviously statistical difference.Conclusion THP, HCPT bladder perfusion SBC relapse prevention effect isobviously better than that of MMC, and which are low incidence of adverse reactionsand worthy of clinical popularization and application.