Expression And Significance Of Tumor Necrosis Factor-a And Interleukin-1β In The Coxa Synovial Membrane Of Perthes Disease

Objective:To study the expression of TNF–a and IL-1β in the coxa synovial membrane ofPerthes disease, And analyze the correlation between TNF-a and IL-1β in Perthesdisease, Preliminary discussion TNF-a and IL-1β in Perthes disease occurrence anddevelopment of the role in the process.Methods:Immunohistochemistry and image analysis were employed to detect theexpression of Tumor Necrosis Factor-a and Interleukin-1β in the coxa synovialmembrane of55specimens of the Perthes disease group and20specimens of thecontrol group．There were4specimens from hip disarticulation and16specimensfrom hip fracture specimens in the control group．Results:The positive rate of TNF–a and IL-1βin Perthes disease coxa synovial membranewere significante higher than that in the control group， had statisticalsignificance(TNF-a（χ2=47.46, p＜0.005）,IL-1β(χ2=38.64, p＜0.005))；And we findthat at the different catterall stages,the expression of TNF–a and IL-1βwas alsodifferent, the expressions of Ⅱ stages are strongly positive, the expressions of Ⅲstages are mainly positive,in the Ⅳ stage, the expression is mainly weakly positive.the difference was significant (TNF-a（χ2=76.09, p＜0.005）,IL-1β(χ2=77.90, p＜0.005))； the coefficient correlation of Tumor Necrosis Factor-a to theInterleukin-1βexpresse in Perthes disease was0.382(P=0.004)，positive．Conclusions:Tumor Necrosis Factor-a and Interleukin-1β might have a hand in the growth and development of the pathogenesis of Perthes disease．...