Prognostic Factors Of Postoperative Radiotherapy For Cerebral Gliomas

Objective: To analyze the relative prognostic factors of postoperativeradiotherapy for patients with cerebral glioma.Methods: The clinical data of102cerebral glioma patients treated withpostoperative radiotherapy in the Department of Oncology, the First AffiliatedHospital of Nanchang University from January2010to October2012was retrosp-ectively reviewed.The median survival time, one-year survival rate and two-yearsurvival rate was calculated by using Kaplan-Meier method.And then this methodwas used for univariate analyses,while Log-rank method for significant test. Therewere ages, degree of tumor surgery resection, pathological grading, time from surgeryto radiotherapy, KPS before radiotherapy for patients, wether concurrentradiochemotherapy six prognostic factors for univariate analyses. Cox regressionmodel was used for multivariate analyses with the statistically significant prognosticfactors.And describe the corresponding survivorship curves respectively with theKaplan-Meier method.Results：Ultimately, the overall median survival time was19months.And theoverall one-year survival rate was70.6%, the two-year survival rate was36.9%。Through the univariate analyses, the patients with age<40years old、tumor totalremoval、grade I to II and concurrent radiochemotherapy had longer overall survivalrelated time（P<0.05）.By the Cox multivariate analyses, age、degree of tumor surgeryresection、 pathological grading and wether concurrent radiochemotherapy wereindependent prognostic factors（P<0.05）.Conclusion: Age,degree of tumor surgery resection,pathological grading andwether concurrent radiochemotherapy are the significant prognostic factors whichaffect the clinical effect of radiotherapy for postoperative cerebral gliomas. Thepatients with age<40years old,lower pathological grading,more radical resectiondegree, treated with concurrent temozolomide radiochemotherapy have betterprognosis. On the contrary, the patients with age≥40years old,higher pathologicalgrading,less radical resection degree, treated with radiotherapy alone have poorer prognosis.