Research On Synthesis Of Cefoxitin

Cefoxitin, the second-generation cephalosporins is permanece and have a broad spectrum of antibacterial activity. Because of its strutural characteristics. It has a high resistance to theβ-lactanase, which producted by bacteria. Thus, the cefoxitin has a great market potential.Starting from cephalosporanic acid as raw material, the cefoxitin was obtained via 4 steps amidation, methoxylation, deacetylation, and carbamo -ylation. We have improved the original process., the total yield of 71.5%. In the amidation reaction, we selected cephalosporanic acid as a reaction macterial which is simpler and lower; in reaction methoxy we selected tert-butyl hypochlorite to repalce the NBS as the halogenated reagent reduce the cost applicable for mass production; in the deacetylation reaction, we use enzymes as reagents to acetylation, and all intermediate conditions were optimized to obtain a low cost, simple green industrial synthesis route.