Synthesis Of Ceramide Analogs And Study Of Their Bioactivities

Ceramides and sphingolipids are major components of cellular membranes especially for central nervous system cells in most animals and plants. In recent years, the development of technology has shown us the bioactivities of these compounds including cell adhesion, cell differentiation, cell proliferation, signal transduction, cell apoptosis and other vital roles in basic cell process. In the past twenty years, scientists have done plenty works on synthesis of these compounds and analogs since their outstanding bioactivities although the structures are complicated. In fact, most of these synthetic schemes are long as well as low final yielding therefore the research of compounds possessed similar structure and low molecular weight became necessary.In this thesis, we synthesized 39 compounds including 25 novel compounds from three kinds of materials, which have similar structures in compared with ceramides’chiral part. The key step of the scheme is high yielding amidation and finally, structures of part compounds are characterized by IR, 1HNMR, MS and other spectrum methods.While testing antitumor activities of these compounds, the results are frustrating: most compounds show no antitumor effect and several compounds show weak antitumor activity.In the test of neurotrophic activitity, compound (L-2-12) can greatly promoting the growth and differentiation of PC12 neurite in the presence of 2 ng/ml. The structure-activity relationship deserve further research.