The Effects Of Yeast Extract Riched In Nucleotide On Growth, Blood Biochemical Indexes And Intestinal Mucosa Morphology Of Piglets

This experiment was conducted to investigate the effects of Yeast extract (YE) on growth performance and intestinal mucosa morphology of early-weaned piglets.150 DurocxLandracex Yorkshire piglets from 15 pens (average pen weight 6.22±0.16 kg; weaned at 21±1 d) were grouped into 3 treatment groups, and fed one of the following diets for 14 days:a control diet, a SDPP diet (SDPP,30 g/kg), and a YE diet supplemented with 30 g/kg YE replacing SDPP. On day 15, five piglets were randomly selected from each replicate for blood samples, and then slaughtered for jejunum and ileum collections. The results are as follows:1. Growth performance indicatorsCompared with the control group, the supplementation of 3% SDPP or 3% YE could significantly decrease diarrhea rate(P<0.05), but there were no significant difference between the SDPP group and the YE group on growth performance indicators (P>0.05).2. Blood biochemical indicators and organ indexesCompared with the SDPP group, the serum glucose decrease by 15.3% (P>0.05), urea increased by 28.5% (P>0.05) and P in serum of the piglets decreased by 10.52% (P<.05) in the YE group. Meanwhile, compared with the SDPP group, the liver index decreased markedly (P<0.01) and the renal index had a decrease tendency in the YE group (P=0.069).3. Plasma amino acids concentrationsIn essential amino acids (EAA), compared with the control group, plasma lie increased significantly in the SDPP and YE groups (P<0.05), plasma Val increased in the YE group (P<0.05). And compared with the SDPP group, plasma Trp concentration in the YE group decrease significantly (P<0.05).In non-essential amino acids (NEAA), compared with the SDPP group, plasma Gin and Glu concentrations decreased by 19.9% (P<0.05) and 19% (P>0.05) in the weanling piglets from YE group.4. Intestinal mucosa morphologyCompared with the control group, the jejunum villus height (VH) in the two experimental groups increased significantly (P<0.05). Furthermore, compared with the SDPP group, there is a significant decrease in ileum villus height in the piglets from the YE group, and ileum V/C had an increased tendency in the YE group.5. Blood hormone levelsCompared with the SDPP group, serum triiodothyronin (T3) level increased significantly and thyroxin (T4) content had an increased tendency (P>0.05).The results showed that:(1) Dietary of supplementation with SDPP or YE had similar effects on growth performance of piglets; (2) Some plasma EAA and NEAA concentrations decreased, and serum T3 & T4 levels increased in YE group compared with SDPP group, which indicated YE supplementation during the immediate post-weaning could improve the efficiency of amino acid utilization and promote protein deposition; (3) Compared with the control group, ileum mucosa morphology improved in YE group, which was benifical to improve the absorption efficiency of nutrients and reduce diarrhea rate.In conclusion, SDPP can be replaced by YE without any detrimental effect on growth performance in early-weaned piglets.