Synthesis Of Diniconazole Compounds And Study On Its Corrosion Resistant Character In The Wood

Diniconazole is a new type of fungicide with broad spectrum, high efficiency and low toxicityto humans and animals. In order to obtain the wood preservatives with broad-spectrum and long-lasting characteristics, seven compounds were synthesized with a-trizaole pinacolone as rawmaterials. The structures of7compounds were confirmed by MS and1H NMR. The targetcompounds were tested for antimicrobial activity against white-rot fungus (Coriolus versicolor),brown-rot fungus (Gloeophyllum trabeum) and moulds (Aspergillus niger) by agar-well diffusionmethod. Otherwise, these compounds were evaluated in performance of anti-mould, anti-decayand leaching resistance as wood preservatives. The results showed that they have the distinctadvantages compared with Diniconazol. The results of the research were summarized as follows:1. According to the antifungal mechanism and structure-activity relationship of triazolecompounds, keeping key active group1,2,4-triazole, changing the substituents on the benzene ringand using a-trizaole pinacolone as raw material, seven compounds were synthesized throughnucleophilic substitution、aldol condensation and reduction reaction., beginning with a-trizaolepinacolone.2. The antibacterial properties of the target compounds were tested. The results show that4b、4c、4e、4g and4h have a good inhibitory effects on wood-decaying fungi and4e hasstronger effects than diniconazole on Gloeophyllum trabeum Aspergillus niger.3. The anti-mildew experiments results of target compounds showed that the infection valuesof wood samples treated by target compounds were decreased with the increase of the absorptiondose, which were invaded by aspergillus niger, decreased and the mildew resistance became moresignificant. From the view of the grading standards of fungus resisitance, the antifungal effect of4c、4e and4h on aspergillus niger was better than diniconazole used as controlled reagent. Theantifungal effect of4b、4d and4f on aspergillus niger was worse than diniconazole,4d and4f haseven no antifungal effect.The study also showed that in terms of4c, the grading standards offungus resisitance reached the level0in retention of3.79g/m2, while the retention should beachieved to4.98g/m2for4e. The requirements of practical application was preliminary achieved.4. The result of anti-decay test in labs showed that weight loss rate of wood samples treatedby the compounds decreased with the increase of retention, that meant the anti-decay effectsgradually became increased stronger with the increase of retention. The results also indicated that,in the same retention, anti-decay ability orders were as fellows:4e、4h、diniconazole、4g、4b、4d on Gloeophyllum trabeum and4c、4h、diniconazole、4g、4e、4b、4d on Coriolusversicolor. When the retention of4c、4g、4h were200g/m3、400g/m3、300g/m3，respectively, their mass loss rate were8.2%、9.8%and9.2%to Coriolus versicolor reaching the woodpreservative level Ι；The wood preservative of4e and4h could reach level Ι to Gloeophyllumtrabeum in the retention of200g/m3and300g/m3, which the mass loss of them were8.4%and8.9%respectively.5. The results of leaching resistance experiments showed that the loss amount of thecompounds and tebuconazole gradually increased with the increase of the absorption dose in thewoods and loss rates of the compounds and tebuconazole gradually decreased with the increase ofthe absorption dose in the woods.4h was the best in loss rate, fixation and anti-leaching and lossrate was only7.7%in retention500g/m3;4c was second in loss rate, fixation and anti-leaching andloss rate was only7.7%in retention500g/m3; but loss rate of diniconazole was7.5%in the sameretention and diniconazole had lowest loss rate.