| By infusing chemotherapy drugs within a specific temperature range into patent’s abdominal cavity, intraperitoneal hyperthermic chemotherapy(IHCT) combines efficacy of hyperthermia and chemotherapy on tumor treatment and achieves satisfactory curative effects in treating abdominal cancer, inhibiting peritoneal metastasis and decreasing the postoperative recurrence rate. Developing an IHCT machine according to requirements of IHCT treatment is of significant meaning in improving health level and living quality of the people.According to IHCT treatment, working performance requirements of solution circulation pipe, solution temperature control, human-machine interaction as well as safe operation are acquired in this paper and an IHCT machine is developed. Heating board power tuning system, pump control system, temperature data acquiring system and step motor control system are described in detail in control system developing section,whose core is based on a DSP chip. At the software level, intelligent monitoring software is developed with C# on HMI machine, which can be applied to control treatment process, send commands and analysis temperature signals; Slave machine program are developed using C language in order to acquire temperature data and drive heating board power tuning system as well as pump control system functioning automatically in temperature control and flow rate control.Concentrating on the issue of solution temperature control, which is the key factor in IHCT process, solution temperature control system is analyzed in detail in this study. A mathematical model on solution heating process whose fitting accuracy surpasses 90% is obtained using system identification technique and temperature control strategy is designed on the basis of the mathematical model and parameters are optimized in MATLAB SIMULINK. A series of experiments indicate that solution temperature rises rapidly and steady- state error is below ±0.1℃. By analyzing heat exchange process in abdominal cavity and using fuzzy logic control strategy, flow rate-temperature control system of abdominal cavity is designed in this paper.In the end, functions of IHCT machine are verified by laboratory simulation experiments and animal experiments; solution temperature control effects are obtained using temperature data acquired in the experiments and safety assessment in IHCT treatment are also evaluated by analyzing blood data, breath data as well as anastomotic healing status of the subject. |
