Preparation Of PVA Hydrogel Used As Wound Dressing By Trimethylol Melamine

Recently, various soft materials, especially hydrogels, with excellent properties of adsorption, have aroused tremendous interests due to their wide applications in medical and surgical aspects. However, many practical uses of conventional dressing are still severely limited by their poor performance, such as easy drying, weak adsorption properties and harm to wound. At present, domestic and foreign researches mainly focus on Acrylamide, chitosan, hyaluronic acid, alginate, polyvinyl alcohol(PVA). Taking consideration of safety and economic performance of raw materials, polyvinyl alcohol was preferred for researchers and used for the preparation of hydrogel.Several methods have been applied in preparation of polyvinyl alcohol hydrogel including physical crosslinking, radiation crosslinking and chemical crosslinking. However, radiation crosslinking could be more vulnerable to the constraints of irradiation depth, radiation type and light intensity of light source. Although the hydrogels formed by chemical crosslinking have a more stable crosslinking structure and overcome the limit of forming thickness, they are too heavily dependent on the crosslinking agent, especially bifunctional crosslinking agent. In this work, we present a novel trimethylolmelamine crosslinking agent, PVA hydrogels are synthesized by using trimethylolmelamine as crosslinkers. These hydrogels showed good adhesive.Although the adhesive of PVA hydrogels has been improved significantly, the mechanical properties of the hydrogels are relatively poor. Similar to theory of fiber reinforced plastics, the polyvinyl alcohol hydrogels could be reinforced by celluloses, we found that the mechanical properties of hydrogels have been increased significantly.