Preparation Of Drug Controlled Released Pet Fabric By Hollow Mesoporous Silica

Polyester(PET) fabrics are widely used in biomedical fields because of its excellent properties such as high strength, good elasticity, good heat resistance, corrosion resistance and biocompatibility. Nowadays, the functional fabrics have some drawbacks, such as poor effect, technology finite. Layer-by-layer assembly technology is a method which involves the alternate spraying of aqueous solutions of oppositely charged polyelectrolytes onto substrate surfaces, is a facile, practical and easy-to-use method for the fabrication of functional films. In the research, we functionalize the surface of PET fabrics with pH stimulus response of controlled release hollow mesoporous silica nanoparticles using layer by layer assembly method.Compared to mesoporous silica(MSN), HMS can load more rhodamine B(RhB), which proved by the pictures of centrifugal supernatant after loading different concentration of the RhB solution for 21 h. The drug-loading rate of HMS and MSN were 26.80% and 8.24% respectively in the 0.5 mg/mL mass concentration RhB solution. This prove that HMS have obvious characteristics of the high loading property. The two kinds of nanoparticles with RhB release drug in deionized water. HMS has the more rapid release speed compared with MSN from the release kinetics curves.Secondly, polymerized dopamine(PDA) was coated on the surface of HMS then foring a pH sensitive film. Characterized the(HMS-RhB) @PDA drug release properties by releaseing drug under acid(phosphate buffer solution(PBS), pH = 3) and the weak alkaline(PBS, pH = 7.4) environment respectively then get the kinetics curves. The film thickness was 7.15±0.5 nm. The(HMS-RhB) @PDA nanoparticles release drug in acidic and alkaline environments: the release rate was stable within 10 h in acidic environment, which is the characteristics of drug controlled release; the release kinetics curve under acid condition get finally release with 93.21%, which is 2.7 times compared with the finally release 34.34% under weak alkali conditions.Thirdly, through the layer-by-layer assembly methods, PET fabrics were coated with(HMS-RhB) @PDA and polyene propyl amine hydrochloride(PAH), and 1-6 layers PET functional fabrics have been gotten. The 6 kinds of PET functional fabrics were characterized with SEM and ventilation rate texts. With the increase of the number of layers, more nanoparticles were on the fabrics, and fabrics from of 6 layers permeability is decreased by 37.36% compare with original. PET functional fabrics were released in acid(PBS, pH = 3) and the weak alkaline(PBS, pH = 7.4) circumstances. The release rate was stable in 12 h, reached the requirements of drug controlled release, and the release quantity of acidic environment is 3.93 times of weak alkaline environment at 12 h. The finally release of acidic environment is 3.03 times with weak alkaline environment, reflects the pH stimulus response characteristics. Compare with the released contrast of PET functional fabrics and nano particles, PET functional fabrics eventually release 3.03 times, more than the 2.7 times of nanoparticles, because the functional method was using particles and PAH molecules between positive and negative charges in combination, which influencing the responsibility, and the effect on the release of the weak alkaline environment influence is relatively larger. Then the fabrics were characterized after releaseing drug by UV-vis spectra, and the fabric release from weak alkaline environment contains more RhB because the fabric release less RhB. And this proved that nanoparticles were still on the surface of PET fabrics, and layer by layer method structure was stable, and did not have influence in the release environment.In conclusion, PET functional fabrics have the pH stimulus response of controlled release performance, and this technology can be used in the PET biomedical fabrics in order to solve the current problem of PET biomedical fabrics, which is promising in research and market application.